DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-2 and HXT4

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_011960.2	Gene:	HXT4 / 856492	SGDID:	S000001134	Length:	576	Species:	Saccharomyces cerevisiae

Alignment Length:	496	Identity:	131/496 - (26%)
Similarity:	225/496 - (45%)	Gaps:	93/496 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 AALSVSLCSLVV---GFVSAY---TSPALVSMTDRTITSFEVTKDAGSW---------VGGIMPL 80
            |.::||:|.|:|   |||..:   |....|:.|| .|..|.:....|::         :..|..:
Yeast    67 AYVTVSICCLMVAFGGFVFGWDTGTISGFVAQTD-FIRRFGMKHHDGTYYLSKVRTGLIVSIFNI 130

  Fly    81 AALAGGITGGPLIEYLGRRSTILATAVPFIVSSLLIACAVNV-IMILCGRFLTGFCV-GIASLSL 143
            ....|||....|.:..||:..::...|.:|:..::...::|. .....||.::|..| |||.||
Yeast   131 GCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLS- 194

  Fly   144 PVYLGETLQPEVRGTLGLLPTALGNIGILVCYVAG-------SFMNWSMLAFLGAALPVPFLILM 201
            |:.:.|.....:||||......:..:||.:.|...       :.:.|.:...||.|..:..:..|
Yeast   195 PMLISEVSPKHIRGTLVSCYQLMITLGIFLGYCTNYGTKTYTNSVQWRVPLGLGFAWALFMIGGM 259

  Fly   202 IIIPETPRWFVNRGQEERARKALKWLRGKEADVEPELK---ELMQSQADADRQATQNTCLELFKR 263
            ..:||:||:.|..|:.|.|::::. |..|.:..:|.:.   |::|:..:|::.|...:..|:|..
Yeast   260 TFVPESPRYLVEVGKIEEAKRSIA-LSNKVSADDPAVMAEVEVVQATVEAEKLAGNASWGEIFST 323

  Fly   264 NNLKPLSISLGLMF--FQQFSGINAVIFYTVQIFKDAGSTIDSNLSTIIVGVVNFFATFMGIILI 326
            .......:.:|.|.  .||.:|.|...:|...:|...|.. ||..::|::|:|||.:||:||.|:
Yeast   324 KTKVFQRLIMGAMIQSLQQLTGDNYFFYYGTTVFTAVGLE-DSFETSIVLGIVNFASTFVGIFLV 387

  Fly   327 DRLG-RKILLY--VSDIAMIVTLSILGGFFYCKAHGPDVSHLGW----------------LPLTC 372
            :|.| |:.||:  .|..|.:|..:.:|           |:.| |                :..||
Yeast   388 ERYGRRRCLLWGAASMTACMVVFASVG-----------VTRL-WPNGKKNGSSKGAGNCMIVFTC 440

  Fly   373 FVIYILGFSLGFGPIPWLMMGEILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTVAMGAHGAF- 436
            |  |:..|:..:.|||:::..|..|.:::....::..|.||...|::              |.|
Yeast   441 F--YLFCFATTWAPIPFVVNSETFPLRVKSKCMAIAQACNWIWGFLI--------------GFFT 489

  Fly   437 -WLFGAI----------CIV-GLFFVIIFVPETRGKSLEEI 465
             ::.|||          |:| ..|:|..|||||:|.:|||:
Yeast   490 PFISGAIDFYYGYVFMGCLVFSYFYVFFFVPETKGLTLEEV 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	131/496 (26%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	121/481 (25%)
HXT4	NP_011960.2	Sugar_tr	74..534	CDD:395036	128/489 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342777
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13432
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	6	5.640