DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-2 and HXT14

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_014081.1	Gene:	HXT14 / 855398	SGDID:	S000005262	Length:	540	Species:	Saccharomyces cerevisiae

Alignment Length:	531	Identity:	125/531 - (23%)
Similarity:	232/531 - (43%)	Gaps:	110/531 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KILMRADTHVSFSVPADGLKANFTFSQVLAALSVSLCSLV----VGFVSAYTSPALVSMTDRTIT 62
            ||...|..|:                .||..|.:||...:    :|.:...|:  :||..::..|
Yeast    50 KISHNASLHI----------------PVLLCLVISLGGFIFGWDIGTIGGMTN--MVSFQEKFGT 96

  Fly    63 SFEVTKDAGSWVG-------------GIMPLAALAGGITGGPLIEYLGRRSTILATAVPFIVSSL 114
            :..:..|...:|.             .|..::...|.:|...:.:::||:..|.        .:|
Yeast    97 TNIIHDDETIFVSTKKLTDLQIGLIISIFNISCGVGALTLSKIGDWIGRKGGIW--------FAL 153

  Fly   115 LIACAVNVIMIL---------CGRFLTGFCVGIASLSLPVYLGETLQPEVRG----------TLG 160
            ::.|....|.||         .||.:||..||:.::.:|::|.|....::||          |.|
Yeast   154 VVYCIGITIQILSYGRWYFLTLGRAVTGIGVGVTTVLVPMFLSENSPLKIRGSMVSTYQLIVTFG 218

  Fly   161 LLPTALGNIGILVC---------YVAGSFMNWSMLAFLGAALPVPFLILMIIIPETPRWFVN-RG 215
            :|   :|||...:|         .:|     |.:..|||....:...:.::.:||:|::... :.
Yeast   219 IL---MGNILNFICERCYKDPTQNIA-----WQLPLFLGYIWAIIIGMSLVYVPESPQYLAKIKN 275

  Fly   216 QEERARKALKWLRG---KEADVEPELKELMQSQADADRQATQNTCLELFKRNNL-----KP---- 268
            ....|:.:...:.|   .::.|...:.:|:::..:.:....::....|.|||..     ||
Yeast   276 DVPSAKYSFARMNGIPATDSMVIEFIDDLLENNYNNEETNNESKKQSLVKRNTFEFIMGKPKLWL 340

  Fly   269 -LSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDSNLSTIIVGVVNFFATFMGIILIDRLGRK 332
             |.|.:.:|.|||.||||...:|...:||..|.. |..:::||:..|||.:|.:||..:::.|.|
Yeast   341 RLIIGMMIMAFQQLSGINYFFYYGTSVFKGVGIK-DPYITSIILSSVNFLSTILGIYYVEKWGHK 404

  Fly   333 -ILLYVSD--IAMIVTLSILGGFFYCKAHGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGE 394
             .|||.|.  :..::|.:.:|.|    ....|.|::..:.:||  .:|..|::..||:.::::.|
Yeast   405 TCLLYGSTNLLFYMMTYATVGTF----GRETDFSNIVLIIVTC--CFIFWFAITLGPVTFVLVSE 463

  Fly   395 ILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTVAMGAHGAF---WLFGAICIVGLFFVIIFVPE 456
            :.|.:.|..:.::.|..||...|:::.    ||..:.:...|   ::|.|..:..:.|..|.|||
Yeast   464 LFPLRTRAISMAICTFINWMFNFLISL----LTPMIVSKIDFKLGYIFAACLLALIIFSWILVPE 524

  Fly   457 TRGKSLEEIER 467
            ||.|:.:||.:
Yeast   525 TRKKNEQEINK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	119/500 (24%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	111/485 (23%)
HXT14	NP_014081.1	MFS_HXT	62..537	CDD:340914	120/503 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.710