DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-2 and HXT3

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_010632.1	Gene:	HXT3 / 851946	SGDID:	S000002753	Length:	567	Species:	Saccharomyces cerevisiae

Alignment Length:	514	Identity:	139/514 - (27%)
Similarity:	227/514 - (44%)	Gaps:	94/514 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FSVPADGLKANFTFSQVL--------AALSVSLCSLVV---GFVSAY---TSPALVSMTDRTITS 63
            |...||         |||        |.::||:|.::|   |||..:   |....|:.|| .:..
Yeast    41 FQAEAD---------QVLTNPNTGKGAYVTVSICCVMVAFGGFVFGWDTGTISGFVAQTD-FLRR 95

  Fly    64 FEVTKDAGSW---------VGGIMPLAALAGGITGGPLIEYLGRRSTILATAVPFIVSSLLIACA 119
            |.:....||:         :..|..:....|||....|.:..||:..::...|.:|:..::...:
Yeast    96 FGMKHKDGSYYLSKVRTGLIVSIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIAS 160

  Fly   120 VNV-IMILCGRFLTGFCV-GIASLSLPVYLGETLQPEVRGTLGLLPTALGNIGILVCYVA----- 177
            :|. .....||.::|..| |||.|| |:.:.|....|:||||......:..:||.:.|..
Yeast   161 INKWYQYFIGRIISGLGVGGIAVLS-PMLISEVAPKEMRGTLVSCYQLMITLGIFLGYCTNFGTK 224

  Fly   178 --GSFMNWSM---LAFLGAALPVPFLI-LMIIIPETPRWFVNRGQEERARKALKWLRGKEAD--- 233
              .:.:.|.:   |.|..|.    |:| .|..:||:||:.|..||.:.||.:|..:.....|
Yeast   225 NYSNSVQWRVPLGLCFAWAL----FMIGGMTFVPESPRYLVEAGQIDEARASLSKVNKVAPDHPF 285

  Fly   234 VEPELKELMQSQADADRQATQNTCLELF--KRNNLKPLSISLGLMFFQQFSGINAVIFYTVQIFK 296
            ::.|| |::::..:..|.|...:..|||  |....|...:.:.:...||.:|.|...:|...:|.
Yeast   286 IQQEL-EVIEASVEEARAAGSASWGELFTGKPAMFKRTMMGIMIQSLQQLTGDNYFFYYGTTVFN 349

  Fly   297 DAGSTIDSNLSTIIVGVVNFFATFMGIILIDRLGRKILLYVSDIAMI---VTLSILGGFFYCKAH 358
            ..|.: ||..::|:.||||||:|...:..:||.||:..|....|.|:   |..:.:|
Yeast   350 AVGMS-DSFETSIVFGVVNFFSTCCSLYTVDRFGRRNCLLYGAIGMVCCYVVYASVG-------- 405

  Fly   359 GPDVSHLGW----------------LPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGPAASV 407
               |:.| |                :...||  ||..|:..:.||.::::.|..|.:::..|.|:
Yeast   406 ---VTRL-WPNGEGNGSSKGAGNCMIVFACF--YIFCFATTWAPIAYVVISETFPLRVKSKAMSI 464

  Fly   408 VTAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICIV-GLFFVIIFVPETRGKSLEEI 465
            .||.||...|::......:|.|:..:..:...|  |:| ..|:|..|||||:|.:|||:
Yeast   465 ATAANWLWGFLIGFFTPFITGAINFYYGYVFMG--CMVFAYFYVFFFVPETKGLTLEEV 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	133/488 (27%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	123/473 (26%)
HXT3	NP_010632.1	Sugar_tr	65..525	CDD:395036	130/481 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342772
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	5	4.640