DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-2 and slc2a10

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001072926.1	Gene:	slc2a10 / 780388	XenbaseID:	XB-GENE-950490	Length:	555	Species:	Xenopus tropicalis

Alignment Length:	557	Identity:	145/557 - (26%)
Similarity:	246/557 - (44%)	Gaps:	132/557 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 VLAALSVSLCSLVVGFVSAYTSPA-LVSMTDRTITSFEVTKDAGSWVGGIMPLAALAGGITGGPL 92
            :|||....|..:|.|:.....|.| ||..|...:|.||......:.:.|.: ||:|.|||    :
Frog     9 ILAATVSLLGGIVFGYELGIISGALLVLKTVYQLTCFEQEALVSAVLFGAL-LASLIGGI----I 68

  Fly    93 IEYLGRRSTILATAVPFIVSSLLIACAVNVIMILCGRFLTGFCVGIASLSLPVYLGETLQPEVRG 157
            |:..|||:.|||:.:..:..|:::........::.||...||.:.|:|::..:|:.|.::|..||
Frog    69 IDRWGRRTAILASNLVVLAGSIILIATSTFWWLIVGRVTIGFAISISSMACCIYVSEIVRPHQRG 133

  Fly   158 TL-GLLPTALGNIGILVCYVAGSFM-----NWSMLAFLGAALPVPF-LILMIIIPETPRWFVNRG 215
            .| .|..|.: .:|||:.|....|:     :|..:..| |.:|..| .|.::.:|..|
Frog   134 MLVSLYETGI-TVGILISYAMNYFLSGVNESWKYMFGL-AIVPAAFQFISILFLPSKP------- 189

  Fly   216 QEERARKALKWLRGKEADVEPELKELMQS----QADADRQATQNTCLELFK-RNNLKPLS-ISLG 274
                 .|...|    |.|.:....||.::    :...|....|.|.|:||: ::|::..: :.||
Frog   190 -----HKLNFW----EQDTDDGFIELEETGEAGEFKPDTYDRQYTFLDLFRSKDNMRTRTLLGLG 245

  Fly   275 LMFFQQFSGINAVIFYTVQIFKDAGSTIDSN--LSTIIVGVVNFFATFMGIILIDRLGRKILLYV 337
            |:.||||:|...|::|...||:..|...:|:  |:::.:|||...:|.:.|...|:.||:|||..
Frog   246 LVLFQQFTGQPNVLYYASTIFQSVGFQSNSSAVLASVGLGVVKVASTLIAICFADKAGRRILLLA 310

  Fly   338 SDIAMIVTLSILG---------------------------------GFFYCK------------- 356
            ..|.|.:.::.:|                                 |..:.:
Frog   311 GCIVMTIAITGIGIVSFTVKMDSHRDCGSVTGRNMSSGESNVSQLLGIVHAETSTINTLDNSVHQ 375

  Fly   357 ----------AHGPDVSH-----------------------LGWLPLTCFVIYILGFSLGFGPIP 388
                      |:....:|                       |.|:.|...:.::..||:||||:.
Frog   376 LAMAIRSPSLANSASSNHKDLISQNSTVLPASPELPSNYTILNWITLLSMMAFVSAFSIGFGPMT 440

  Fly   389 WLMMGEILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICIVGLFFVIIF 453
            |:::.||.||.|||.|.:...:|||....::|.||.|:..::|....|.|:|.:.::.:.|:..|
Frog   441 WIVLSEIYPADIRGRAFAFCNSFNWAANLLITLTFLDVIASIGLSWTFLLYGVVGLLAIAFIYFF 505

  Fly   454 VPETRGKSLEEIER--------------KMMGRVPMS 476
            :|||:|:|||||::              |.:|:.|.|
Frog   506 IPETKGQSLEEIDKQFSTKRILQKRETSKGVGKRPSS 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	140/530 (26%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	128/515 (25%)
slc2a10	NP_001072926.1	MFS_GLUT10_Class3	10..517	CDD:340994	139/529 (26%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	250..256		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..555		4/15 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D524131at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920