DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-2 and slc2a10

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001104633.1	Gene:	slc2a10 / 560546	ZFINID:	ZDB-GENE-080204-6	Length:	513	Species:	Danio rerio

Alignment Length:	524	Identity:	144/524 - (27%)
Similarity:	240/524 - (45%)	Gaps:	94/524 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SQVLAALSVS-LCSLVVGFVSAYTSPALVSMTDRTITSFE---VTKDAGSWVGGIMPLAALAGGI 87
            |.:|..::|| |..||.|:.....|.||..:.    |.|.   |.::|   |...:.:.:|...|
Zfish     4 SVLLLTITVSTLGGLVFGYELGIISGALPQLQ----THFSLGCVQQEA---VVSALLIGSLFASI 61

  Fly    88 TGGPLIEYLGRRSTILATAVPFIVSSLLIACAVNVIMILCGRFLTGFCVGIASLSLPVYLGETLQ 152
            .||.||:..|||::||.:.:..:..|:::....:...::.||.:.||.:.::|:|..:::.|.:.
Zfish    62 IGGWLIDRHGRRTSILLSNLLILTGSVILTTGTSFFALVIGRAVIGFAMTVSSMSCCIFVSEMVT 126

  Fly   153 PEVRGTLGLLPTALGNIGILVCYVAGSFMN------WSMLAFLGAALPVPFLILM---IIIPETP 208
            ||.||.:..|......:|||:.|....|.|      |..:  .|.|: :|.||.:   :::|:..
Zfish   127 PERRGLMVTLYEVGVTVGILIAYAVNYFFNNVQLTGWRYM--FGFAI-IPSLIQLASIVLLPKQA 188

  Fly   209 RWFVNRGQEERARKALKWLRGKEADVEPELKELMQSQADADRQATQNTCLELFK-RNNLKPLS-I 271
            ..||....:.|           :||...|..|.......:::....    :||| ::|::..: |
Zfish   189 EVFVIHDDDSR-----------QADRLTEETETSNQHQQSEKYGVS----DLFKSKDNMRRRTVI 238

  Fly   272 SLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDSNLSTIIV----GVVNFFATFMGIILIDRLGRK 332
            .:||:..|||:|...|:||...|....|  ..||.|.|:.    |:|...||.:.::..||.||:
Zfish   239 GVGLVLSQQFTGQPNVLFYASTILFSVG--FQSNASAILASVGFGIVKVIATLLAMLCSDRAGRR 301

  Fly   333 ILLYVSDIAMIVTLSILGGFF----------YCKAHGP---------------------DV-SHL 365
            .|| :...:|:....||.||.          .|.:.||                     || .||
Zfish   302 SLL-IGGCSMLAVGLILTGFLCTQSVIDTTKRCTSVGPHSNLTLSAEHEEGVGFSSQTLDVHEHL 365

  Fly   366 ----------GWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGPAASVVTAFNWFCTFVVT 420
                      .|:..||.:..:..||:.|||:.|:::.||.|..|||.|.|.:..||.....:||
Zfish   366 RSFSQSEDIYKWIIFTCLMAVVSAFSVSFGPMTWVVLSEIFPKDIRGRAFSFINCFNVGTNLIVT 430

  Fly   421 KTFQDLTVAMGAHGAFWLFGAICIVGLFFVIIFVPETRGKSLEEIER-----KMMGRVPMSSVVN 480
            .:|..:...:|..|.|.::|.:.|.|:.|:.:.:|||:||||::|:|     :|:.|..:.|:..
Zfish   431 FSFLSIIDVIGLSGVFLMYGVVGIAGVVFIYLVLPETKGKSLQDIDRELSQTRMIHRQELCSIFQ 495

  Fly   481 IKPF 484
            .:.|
Zfish   496 RRRF 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	137/496 (28%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	129/481 (27%)
slc2a10	NP_001104633.1	MFS	10..463	CDD:119392	129/480 (27%)
		Sugar_tr	11..479	CDD:278511	138/495 (28%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	246..252		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577150
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D524131at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850