DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-2 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_062361.1	Gene:	Slc2a8 / 56017	MGIID:	1860103	Length:	477	Species:	Mus musculus

Alignment Length:	461	Identity:	171/461 - (37%)
Similarity:	256/461 - (55%)	Gaps:	29/461 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LAALSVSLCSLVVGFVSAYTSPALVSMTDRTITSFEVTKDAGSWVGGIMPLAALAGGITGGPLIE 94
            ||:.:.:|..|..||...|:|||:.|:......:..:..:|.||.|.::.|.|.||||.||.|::
Mouse    28 LASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAAAGGILGGWLLD 92

  Fly    95 YLGRRSTILATAVPFIVSSLLIACAVNVIMILCGRFLTGFCVGIASLSLPVYLGETLQPEVRGTL 159
            ..||:.::|...|||:....:|..|.:|.|:|.||.|||...|:|||..|||:.|...|.|||.|
Mouse    93 RAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLL 157

  Fly   160 GLLPTALGNIGILVCYVAGSFMNWSMLAFLGAALPVPFLILMIIIPETPRWFVNRGQEERARKAL 224
            |.....:...|||:.||||..:.|..||.||...|...|:||..:|||||:.:.:.|.:.|..||
Mouse   158 GSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAAL 222

  Fly   225 KWLRGKEADVEPELKELMQSQADADRQATQNTCLELFKRNNL-KPLSISLGLMFFQQFSGINAVI 288
            ::|.|.|...|       :....|:.|..|   |.|.:|..: |||.|.:.||.|||.||:||::
Mouse   223 RFLWGSEEGWE-------EPPVGAEHQGFQ---LALLRRPGIYKPLIIGISLMVFQQLSGVNAIM 277

  Fly   289 FYTVQIFKDAGSTIDSNLSTIIVGVVNFFATFMGIILIDRLGRKILLYVSDIAMIVTLSILGGFF 353
            ||...||::| ...||:|:::.||::....|.:..:::||.||::||.:|.:.|:.::|..|.:|
Mouse   278 FYANSIFEEA-KFKDSSLASVTVGIIQVLFTAVAALIMDRAGRRLLLALSGVIMVFSMSAFGTYF 341

  Fly   354 YCKAHGP-DVSHLG----------------WLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIR 401
            ......| :.||:|                ||.:....::|.||::|:||||||:|.||.|..::
Mouse   342 KLTQSLPSNSSHVGLVPIAAEPVDVQVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVK 406

  Fly   402 GPAASVVTAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICIVGLFFVIIFVPETRGKSLEEIE 466
            |.|..:....|||..|:|||.|..:...:..:|||||..|.|.:.:.|.:..||||:|::||::.
Mouse   407 GVATGICVLTNWFMAFLVTKEFSSVMEMLRPYGAFWLTAAFCALSVLFTLTVVPETKGRTLEQVT 471

  Fly   467 RKMMGR 472
            ....||
Mouse   472 AHFEGR 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	168/453 (37%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	160/438 (37%)
Slc2a8	NP_062361.1	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:16723738	12..13
		Sugar_tr	29..474	CDD:278511	168/455 (37%)
		MFS	31..459	CDD:119392	160/438 (37%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834254
Domainoid	1	1.000	299	1.000	Domainoid score	I1432
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69170
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2627
Isobase	1	0.950	-	0	Normalized mean entropy	S2521
OMA	1	1.010	-	-		QHG52445
OrthoDB	1	1.010	-	-		D524131at33208
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		mtm8886
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R490
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750