DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-2 and slc2a5

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001008187.1	Gene:	slc2a5 / 493549	XenbaseID:	XB-GENE-494009	Length:	517	Species:	Xenopus tropicalis

Alignment Length:	508	Identity:	150/508 - (29%)
Similarity:	244/508 - (48%)	Gaps:	65/508 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DGLKANFTFSQVLAALSVSL-CSLVVGF-VSAYTSPALVSMTDRTITSFE----VTKDA-----G 71
            |..|...|.:.:|..|..:. .|...|: |::..||:.........|:.|    ..:||     .
Frog    11 DERKGRLTATLILVTLVATFGSSFQYGYNVASVNSPSPFMKDFYNSTNIERVGSPLEDAFLTLLW 75

  Fly    72 SWVGGIMPLAALAGGITGGPLIEYLGRRSTILATAVPFIVSSLLIACAV---NVIMILCGRFLTG 133
            |....:.||....|.:..|||:..|||:.|:|...:..|:.::|:..:|   ...:|:..|...|
Frog    76 SLTVSLYPLGGFFGSLLVGPLVSKLGRKGTLLFNNIFSIIPAILMGTSVVAKTFEVIIASRLFVG 140

  Fly   134 FCVGIASLSLPVYLGETLQPEVRGTLGLLPTALGNIGILVC------YVAGSFMNWSMLAFLGAA 192
            .|.|::|..:|:|:||.....:||.:|::|..:..:|||:.      |:.|:...|.:|..|...
Frog   141 VCAGLSSNVVPMYVGEMSPKNLRGAIGIMPQLMITVGILMAQIFGIRYILGNTEGWPILLALTGI 205

  Fly   193 LPVPFLILMIIIPETPRW-FVNRGQEERARKALKWLRGKEADVEPELKELM---QSQADADRQAT 253
            ..|..|..:...||:||: .:::|.|::|:|||:.|||.| ||:.|:||:.   ||:....:.:.
Frog   206 PAVLELAFLPFFPESPRYTLLHKGNEDKAKKALQRLRGWE-DVDSEIKEMYQEDQSEKAEGQLSV 269

  Fly   254 QNTCLELFKRNNLKPLS---ISLGLM-FFQQFSGINAVIFYTVQIFKDAG---STIDSNLSTIIV 311
            :|.|       ..:||.   ||:.:| ..||.||||||.:|...|:|.||   .||  ...|:..
Frog   270 RNLC-------TFRPLRWQLISIIVMNMGQQLSGINAVYYYADSIYKSAGVKEETI--QYVTVAT 325

  Fly   312 GVVNFFATFMGIILIDRLGRKILLYVSDIAMIVTLSILGGFFYC----------KAHGPDVSHLG 366
            |.||...|...:.::|..||::||             |.||..|          ..:...||.:.
Frog   326 GSVNVLMTLAAVFIVDSWGRRVLL-------------LSGFGTCCISCVVLTIALVYQTTVSWMP 377

  Fly   367 WLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTVAMG 431
            :|.:.|.:||::|.::|..|||:::..|:.....|..|..:..:.:|...|::...|:.|...:|
Frog   378 YLSIACIIIYVIGHAIGPSPIPYVITTEMFRQASRPAAFMIAGSVHWLSNFIIGLIFEFLMNGLG 442

  Fly   432 AHGAFWLFGAICIVGLFFVIIFVPETRGKSLEEIERKMMGRVPMSSVVNIKPF 484
            |: .|.||.|||:....|:.|.||||:||:..|:.:.|..|..:...|:.|.|
Frog   443 AY-CFILFAAICLATFIFIYIVVPETKGKTFLEVSQLMAKRNGLEETVDSKEF 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	141/476 (30%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	134/461 (29%)
slc2a5	NP_001008187.1	MFS_GLUT_Class2	24..475	CDD:340990	140/474 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R490
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940