DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-2 and CG8249

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001246349.1	Gene:	CG8249 / 36742	FlyBaseID:	FBgn0034045	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	496	Identity:	140/496 - (28%)
Similarity:	244/496 - (49%)	Gaps:	37/496 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PADGLKANFTFSQVLAALSVSLCSLVVGFVSAYTSPALVSMTDRTITSFEVTKDAGSWVGGIMPL 80
            |..|.:......||:|.:..::.....|...|..:..|..:.| |.....:.....||...:..|
  Fly    33 PPPGEQTRAVRRQVIAVILANVGVFSTGMTLAMPTATLHQLKD-TTEPVHLNDSQASWFASVNAL 96

  Fly    81 AALAGGITGGPLIEYLGRRSTILATAVPFIVSSLLIACA----VNVI--MILCGRFLTGFCVGIA 139
            :|..||:..|.|::.:||:.:::...|..|::.:|:|..    .|..  .::..||:.|..:|:|
  Fly    97 SAPIGGLLSGFLLDRIGRKKSLIVLNVLIILAWILLATPSESDQNAFFWQLIVSRFMLGVGMGLA 161

  Fly   140 SLSLPVYLGETLQPEVRGTLGLLPTALGNI-GILVCYVAGSFM--NWSMLAFLGAALPVPFLILM 201
            |....||..|...|:.||:| :|.|::... ||.:.|..|..:  ::.::|.:.....:..|:.:
  Fly   162 SAPPGVYAAEISVPKTRGSL-ILGTSISVAGGITILYGIGYCIRDDFRLIALICCGYQLVALLCV 225

  Fly   202 IIIPETPRWFVNRGQEERARKALKWLRG-KEAD--VEPELKELMQSQADADRQATQNTCL-ELFK 262
            :.:||:..|.:::.:...|:::|.:.|| .::|  ..|::.|..|....:.:|  :||.: |.|.
  Fly   226 LPLPESHCWLLSKKRVTEAKRSLNYFRGFNKSDEITHPQVLEEFQLLQKSLQQ--RNTAVKESFW 288

  Fly   263 RN-----NLKPLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDSNLSTIIVGVVNFFATF-M 321
            ||     ..|||.|.:.|..|||.:||..||.:.|||.::||..||..:..:::|:.....|. |
  Fly   289 RNLHEPEVYKPLVILMSLFAFQQLTGIFVVIVFAVQISQEAGIEIDPFMCAVLIGLARLITTCPM 353

  Fly   322 GIILIDRLGRKILLYVSDIAMIVTLSILGGFFYCKAHGPDVSHLGWLPLTCFVIYILGFSLGFGP 386
            |.|| :..||:....:|.:.|.|.:.:|.|....:.    :..:.:||:...|.:|:..:||...
  Fly   354 GYIL-EWWGRRRAGIISTLGMSVCMFLLAGHSQIEI----LKEVPYLPVVAIVGFIVLSTLGLYT 413

  Fly   387 IPWLMMGEILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICIVGLFFVI 451
            :|:.|:.|:.|.|:||||:.:..|...|.:|||.||:..:...:|....|.:||.:.:..|.||.
  Fly   414 LPFFMISELFPQKVRGPASGLTVAVGMFISFVVLKTYPGIKEYLGMSNCFIIFGVMALFALIFVY 478

  Fly   452 IFVPETRGKSLEEIERKM-MGR--------VPMSSVVNIKP 483
            :.:||||.::|.|||.:. .||        |.|..|...||
  Fly   479 LALPETRRRTLLEIEEQFRSGRSKSQNQADVEMKEVFVRKP 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	128/454 (28%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	120/439 (27%)
CG8249	NP_001246349.1	MFS	49..479	CDD:119392	120/438 (27%)
CG8249	NP_001246349.1	Sugar_tr	60..496	CDD:278511	128/444 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444593
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2521
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
	7	6.800