DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-2 and SLC2A8

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_055395.2	Gene:	SLC2A8 / 29988	HGNCID:	13812	Length:	477	Species:	Homo sapiens

Alignment Length:	462	Identity:	173/462 - (37%)
Similarity:	254/462 - (54%)	Gaps:	31/462 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LAALSVSLCSLVVGFVSAYTSPALVSMTDRTITSFEVTKDAGSWVGGIMPLAALAGGITGGPLIE 94
            |||.:.:|..|..||...|:|||:.|:......:..:...|.||.|.::.|.|.|||:.||.|::
Human    28 LAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRLDDAAASWFGAVVTLGAAAGGVLGGWLVD 92

  Fly    95 YLGRRSTILATAVPFIVSSLLIACAVNVIMILCGRFLTGFCVGIASLSLPVYLGETLQPEVRGTL 159
            ..||:.::|..:|||:....:|..|.:|.|:|.||.|||...|:|||..|||:.|...|.|||.|
Human    93 RAGRKLSLLLCSVPFVAGFAVITAAQDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLL 157

  Fly   160 GLLPTALGNIGILVCYVAGSFMNWSMLAFLGAALPVPFLILMIIIPETPRWFVNRGQEERARKAL 224
            |.....:..:|||:.|:||..:.|..||.||...|...|:||..:|||||:.:.:.:.:.|..||
Human   158 GSCVQLMVVVGILLAYLAGWVLEWRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAAL 222

  Fly   225 KWLRGKEADVEPELKELMQSQADADRQATQNTCLELFKRNNL-KPLSISLGLMFFQQFSGINAVI 288
            ::|.|.|           |...|....|.|:..|.|.::..: ||..|.:.||.|||.||:|||:
Human   223 RFLWGSE-----------QGWEDPPIGAEQSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVM 276

  Fly   289 FYTVQIFKDAGSTIDSNLSTIIVGVVNFFATFMGIILIDRLGRKILLYVSDIAMIVTLSILGGFF 353
            ||...||::| ...||:|::::|||:....|.:..:::||.||::||.:|.:.|:.:.|..|.:|
Human   277 FYAETIFEEA-KFKDSSLASVVVGVIQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYF 340

  Fly   354 YCKAHGP-DVSH-----------------LGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKI 400
            .....|| :.||                 |.||.:....::|.||::|:||||||:|.||.|..:
Human   341 KLTQGGPGNSSHVAISAPVSAQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHV 405

  Fly   401 RGPAASVVTAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICIVGLFFVIIFVPETRGKSLEEI 465
            :|.|..:....||...|:|||.|..|...:..:|||||..|.||..:.|.:..||||:||:||:|
Human   406 KGVATGICVLTNWLMAFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQI 470

  Fly   466 ERKMMGR 472
            .....||
Human   471 TAHFEGR 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	170/454 (37%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	159/439 (36%)
SLC2A8	NP_055395.2	Dileucine internalization motif. /evidence=ECO:0000250\|UniProtKB:Q9JJZ1	12..13
		xylE	36..472	CDD:182225	167/447 (37%)
		MFS	38..459	CDD:119392	158/432 (37%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	267..273		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144064
Domainoid	1	1.000	301	1.000	Domainoid score	I1411
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69170
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2630
Isobase	1	0.950	-	0	Normalized mean entropy	S2521
OMA	1	1.010	-	-		QHG52445
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		mtm8509
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R490
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750