DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-2 and Slc2a3

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_006505885.1	Gene:	Slc2a3 / 20527	MGIID:	95757	Length:	495	Species:	Mus musculus

Alignment Length:	519	Identity:	156/519 - (30%)
Similarity:	238/519 - (45%)	Gaps:	81/519 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KANFTFSQVLAALSVSLCSLVVGF-VSAYTSPALVSMTDRTITSFEVTKDAGS-------W---- 73
            |.|.|.|.|.|....::.|...|: .....:|..:.......|..|..:|..|       |
Mouse     5 KHNVTPSLVFAVTVATIGSFQFGYNTGVINAPETILKDFLNYTLEERLEDLPSEGLLTALWSLCV 69

  Fly    74 ----VGGIMPLAALAGGITGGPLIEYLGRRSTILATAVPFIVSSLLIA---CAVNVIMILCGRFL 131
                |||::      |..:.|..:...|||:::|...:..|::..|:.   .|.:|.|::.||.|
Mouse    70 AIFSVGGMI------GSFSVGLFVNRFGRRNSMLLVNLLAIIAGCLMGFAKIAESVEMLILGRLL 128

  Fly   132 TGFCVGIASLSLPVYLGETLQPEVRGTLGLLPTALG-NIGILVC------YVAGSFMNWSMLAFL 189
            .|...|:.:..:|:|:||.....:||..|.| ..|| .:||||.      ::.||...|..|..|
Mouse   129 IGIFCGLCTGFVPMYIGEVSPTALRGAFGTL-NQLGIVVGILVAQIFGLDFILGSEELWPGLLGL 192

  Fly   190 --------GAALPVPFLILMIIIPETPRW-FVNRGQEERARKALKWLRGKEADVEPELKELMQSQ 245
                    .||||        ..||:||: .:|:.:|::|.:.|:.|.| .:||..|::| |:.:
Mouse   193 TIIPAILQSAALP--------FCPESPRFLLINKKEEDQATEILQRLWG-TSDVVQEIQE-MKDE 247

  Fly   246 ADADRQATQNTCLELFKR-NNLKPLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDSNLSTI 309
            :....|..|.|.||||:. |.::||.||:.|...||.||||||.:|:..|||||| ..:...:||
Mouse   248 SVRMSQEKQVTVLELFRSPNYVQPLLISIVLQLSQQLSGINAVFYYSTGIFKDAG-VQEPIYATI 311

  Fly   310 IVGVVNFFATFMGIILIDRLGRKILLYVSDIAMIVTLSILGGFFYCKAH-------GPDVSHLGW 367
            ..||||...|.:.:.|::|.||:.|..:.          |||...|...       ..|...:.:
Mouse   312 GAGVVNTIFTVVSLFLVERAGRRTLHMIG----------LGGMAVCSVFMTISLLLKDDYEAMSF 366

  Fly   368 LPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTVAMGA 432
            :.:...:||:..|.:|.|||||.::.|:.....|..|.:|....||...|:|...|......:||
Mouse   367 VCIVAILIYVAFFEIGPGPIPWFIVAELFSQGPRPAAIAVAGCCNWTSNFLVGMLFPSAAAYLGA 431

  Fly   433 HGAFWLFGAICIVGLFFVIIFVPETRGKSLEEIERKMMGR---------VPMSSVVNIKPFPFN 487
            : .|.:|.|..|..|.|....||||:|::.|:|.|...|:         |.::|:..:|..|.|
Mouse   432 Y-VFIIFAAFLIFFLIFTFFKVPETKGRTFEDIARAFEGQAHSGKGPAGVELNSMQPVKETPGN 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	144/478 (30%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	136/463 (29%)
Slc2a3	XP_006505885.1	MFS_GLUT_Class1	14..458	CDD:340989	141/472 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834198
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740