DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-2 and Slc2a1

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_035530.2	Gene:	Slc2a1 / 20525	MGIID:	95755	Length:	492	Species:	Mus musculus

Alignment Length:	446	Identity:	134/446 - (30%)
Similarity:	219/446 - (49%)	Gaps:	62/446 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 YTSPALVSMTDRTITSFEVTKDAGSWVGGIMPLAALAGGITGGPLIEYLGRRSTILATAVPFIVS 112
            |..| :.|.|..|:.|..|         .|..:..:.|..:.|..:...|||:::|...:...|:
Mouse    52 YGEP-IPSTTLTTLWSLSV---------AIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVA 106

  Fly   113 SLLIA---CAVNVIMILCGRFLTGFCVGIASLSLPVYLGETLQPEVRGTLGLLPTALGNIGILVC 174
            ::|:.   ...:..|::.|||:.|...|:.:..:|:|:||.....:||.||.|......:|||:.
Mouse   107 AVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIA 171

  Fly   175 YVAG--SFMN----WSMLAFLGAALPVPFLILMIII---PETPRW-FVNRGQEERARKALKWLRG 229
            .|.|  |.|.    |.:|.   :.:.:|.|:..|::   ||:||: .:||.:|.||:..||.|||
Mouse   172 QVFGLDSIMGNADLWPLLL---SVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRG 233

  Fly   230 KEADVEPELKELMQSQADADRQATQNTCLELFKRNNLK-PLSISLGLMFFQQFSGINAVIFYTVQ 293
             .|||..:|:|:.:......|: .:.|.||||:....: |:.|::.|...||.||||||.:|:..
Mouse   234 -TADVTRDLQEMKEEGRQMMRE-KKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTS 296

  Fly   294 IFKDAG------STIDSNLSTIIVGVVNFFATFMGIILIDRLGRKILLYVS-------DIAMIVT 345
            ||:.||      :||.|       |:||...|.:.:.:::|.||:.|..:.       .:.|.:.
Mouse   297 IFEKAGVQQPVYATIGS-------GIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIA 354

  Fly   346 LSILGGFFYCKAHGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGPAASVVTA 410
            |::|...       |.:|:|..:.:..||.:   |.:|.|||||.::.|:.....| |||..|..
Mouse   355 LALLERL-------PWMSYLSIVAIFGFVAF---FEVGPGPIPWFIVAELFSQGPR-PAAIAVAG 408

  Fly   411 F-NWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICIVGLFFVIIFVPETRGKSLEEI 465
            | ||...|:|...||.:....|.: .|.:|..:.::...|....||||:|::.:||
Mouse   409 FSNWTSNFIVGMCFQYVEQLCGPY-VFIIFTVLLVLFFIFTYFKVPETKGRTFDEI 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	134/446 (30%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	127/433 (29%)
Slc2a1	NP_035530.2	Sugar_tr	19..467	CDD:278511	134/446 (30%)
		MFS	62..450	CDD:119392	123/420 (29%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	282..288		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834354
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740