DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-2 and K08H10.6

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_505572.1	Gene:	K08H10.6 / 187181	WormBaseID:	WBGene00010698	Length:	479	Species:	Caenorhabditis elegans

Alignment Length:	507	Identity:	117/507 - (23%)
Similarity:	229/507 - (45%)	Gaps:	75/507 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKIL-----MRADTHVSFSVPADGLKANFT----FSQVLAALSVSLCSLVVGFVSAYTSPALVSM 56
            ||:|     :....|::..:.|..:.|.|.    |..:::|:: .|..::..|:       :.::
Worm     1 MKVLPLERNLETPPHLTTRLLATSVVATFAGGFHFGYLISAVN-PLSEILQQFI-------VDNL 57

  Fly    57 TDRTITSFEVTKDAGS--W--VGGIMPLAALAGGITGGPLIEYLGRRSTILATAVPFIVSSLLIA 117
            .:|  .|:|::....|  |  :.|.:.:.|:.|......|::.:|.|:::|..|:..:.|:.:..
Worm    58 QNR--YSYELSSSQLSLIWSSLAGCLFIGAMIGAYISIFLLQSIGPRNSLLLAAILQLFSAPVFG 120

  Fly   118 CAVNVIMILC-----GRFLTG--FCVGIASLSLPVYLGETLQPEVRGTLGLLPTALGNIGILVC- 174
            .|.:  :.||     .|.|:|  |.:||::..  |:|.|....:.||....|...:||...|:.
Worm   121 LAYS--LRLCELLPISRILSGIAFAIGISAQG--VFLTEISPAKFRGLTNSLSGLIGNCAFLLAA 181

  Fly   175 -----YVAGSFMNWSMLAFLGAALPVPFLILMII--IPETPRWFVNRGQEERARKALKWLRGKEA 232
                 ||.|:...|..:.|: ..:|....||:.|  ..::|.:.::.|:......|:|...|:..
Worm   182 TLGTPYVLGTVTQWKYIFFI-ETIPCVLHILVNITTFHDSPTYLLSIGKISEGESAIKVYYGETC 245

  Fly   233 DVEPELKELMQSQADADRQATQNTCLELFK-RNNLKPLSISLGLMFFQQFSGINAVIFYTVQI-- 294
                .:|::|:.....|....:.:..::.| :...:.||:::.:.|...||||.|:.|:...:
Worm   246 ----HIKKIMEDLRIIDNGVKEKSLRQILKDKGCAQALSLAVAINFSVAFSGIVAISFFGTFLLQ 306

  Fly   295 ---FKDAGSTIDSNLSTIIVGVVNFFATFMGIILIDRLGRKILLYVSDIAM----IVTLSILGGF 352
               |...||.:.::|.:.    .:..:..:..|.:|::||:.||..|.:.:    |..:|::  |
Worm   307 TIGFSPEGSAVANSLCSF----ASIVSALLAAIAMDKIGRRPLLITSLLVLALINIFMMSLV--F 365

  Fly   353 FYCKAHGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILP----AKIRGPAASVVTAFNW 413
            .|.....   |.|.|..|..||::...||:|.||....:..|:.|    :|::..:.||..|.::
Worm   366 LYDSTKD---SFLAWPFLALFVLFTFVFSIGIGPAAVFIGAELAPPGTISKMQSYSTSVQFAGSF 427

  Fly   414 FCTFVVTKTFQDLTVAMGAHGAFWLFGAICIVGLFFVIIFVPETRGKSLEEI 465
            .|..:    :..|..::|.. ||.||.....:...:..:::|||:|||..||
Worm   428 ICPII----YLQLVESIGGF-AFMLFIVPLTITAAYFYMYLPETKGKSPVEI 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	109/468 (23%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	100/453 (22%)
K08H10.6	NP_505572.1	MFS_GLUT_Class1_2_like	24..469	CDD:340915	107/477 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D524131at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920