DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-2 and Slc2a13

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_598295.2	Gene:	Slc2a13 / 171147	RGDID:	621814	Length:	637	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	149/544 - (27%)
Similarity:	226/544 - (41%)	Gaps:	120/544 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FSQVLAALSVSLCSLVVGFVSAYTSPALV---------SMTDRTITSFEVTKDAGSWVGGIMPLA 81
            |....||.| :|...:.|:.:...|.|::         :|....:.|..|         |...:|
  Rat    69 FVYAAAAFS-ALGGFLFGYDTGVVSGAMLLLRRQMRLGAMWQELLVSGAV---------GAAAVA 123

  Fly    82 ALAGGITGGPLIEYLGRRSTILATAVPFIVSSLLIACAVNVIMILCGRFLTGFCVGIASLSLPVY 146
            |||||...|.    |||||.||..:....|.|.::|.|.|...:|.||.:.|..:||||:::|||
  Rat   124 ALAGGALNGA----LGRRSAILLASALCTVGSAVLAAAANKETLLAGRLVVGLGIGIASMTVPVY 184

  Fly   147 LGETLQPEVRGTLGLLPTALGNIG-ILVCYVAGSFM-----NWSMLAFLGAALPVPFLIL-MIII 204
            :.|...|.:||.|..:.|.....| .....|.|:|.     .|..:..| ||:|.....| .:.:
  Rat   185 IAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKDGWRYMLGL-AAIPAVIQFLGFLFL 248

  Fly   205 PETPRWFVNRGQEERARKALKWLRGKEADVEPELKELMQSQADADRQATQN---TCLELFKRNNL 266
            ||:|||.:.:||.::||:.|..:||.:. ::.|...:..|..:.:::|:..   .|..|......
  Rat   249 PESPRWLIQKGQTQKARRILSQMRGNQT-IDEEYDSIRNSIEEEEKEASAAGPIICRMLSYPPTR 312

  Fly   267 KPLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDSNLS---TIIVGVVNFFATFMGIILIDR 328
            :.|::..||..|||.||||.:::|:..|.:.:| ..|..|:   ..|....||..|.:|:.|:::
  Rat   313 RALAVGCGLQMFQQLSGINTIMYYSATILQMSG-VEDDRLAIWLASITAFTNFIFTLVGVWLVEK 376

  Fly   329 LGRKILLYVSDIAMIVTLSILG-GFF---------------------------YC---------- 355
            :||:.|.:.|.....|.|:||. ||.                           ||
  Rat   377 VGRRKLTFGSLAGTTVALTILALGFLLSAQVSPRVTFRPTAPSGQNATCTEYSYCNECMLDPDCG 441

  Fly   356 -----------------------------------KAHGPDV--------SHLGWLPLTCFVIYI 377
                                               |....||        :...|..|...|:|:
  Rat   442 FCYKINSSAVIDSSCVPVNKASTNEAAWGRCENETKFKAEDVHWAYSFCPTPYSWTALVGLVLYL 506

  Fly   378 LGFSLGFGPIPWLMMGEILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAI 442
            :.|:.|.||:||.:..||.|...|....:.....||....:|:.||......:..:|||:|:...
  Rat   507 VFFAPGMGPMPWTVNSEIYPLWARSTGNACSAGINWIFNVLVSLTFLHTAEYLTYYGAFFLYAGF 571

  Fly   443 CIVGLFFVIIFVPETRGKSLEEIE 466
            ..|||.||...:|||:||.|||||
  Rat   572 AAVGLLFVYGCLPETKGKKLEEIE 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	148/539 (27%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	136/523 (26%)
Slc2a13	NP_598295.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..38
		MFS	75..580	CDD:119392	136/521 (26%)
		Sugar_tr	78..598	CDD:278511	145/534 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337841
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D524131at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750