DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-2 and SLC2A6

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_060055.2	Gene:	SLC2A6 / 11182	HGNCID:	11011	Length:	507	Species:	Homo sapiens

Alignment Length:	489	Identity:	157/489 - (32%)
Similarity:	246/489 - (50%)	Gaps:	37/489 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DTHVSFSVPADGLKANFTFSQ----VLAALSVSLCSLVVGFVSAYTSPALVSMTDRTITSFEVTK 68
            ||......|:.|.:|.....|    .||..:..|.:...|:...||||.:.::.........:||
Human    14 DTFPEKPPPSPGDRARVGTLQNKRVFLATFAAVLGNFSFGYALVYTSPVIPALERSLDPDLHLTK 78

  Fly    69 DAGSWVGGIMPLAALAGGITGGPLIEYLGRRSTILATAVPFIVSSLLIACAVNVIMILCGRFLTG 133
            ...||.|.:..|.|.|||::...|.:.|||:.:|:.:|||......|:|.|..:.|:|.||.|||
Human    79 SQASWFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTG 143

  Fly   134 FCVGIASLSLPVYLGETLQPEVRGTLGLLPTALGNIGILVCYVAGSFMNWSMLAFLGAALPVPFL 198
            |..|:.:..:|||:.|...|.|||.||..|..:...|.|..|..|..:.|..||..|.| ||..:
Human   144 FAGGLTAACIPVYVSEIAPPGVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEA-PVLIM 207

  Fly   199 ILMI-IIPETPRWFVNRGQEERARKALKWLRGKEADVEPELKELMQSQADADRQATQNTCLELFK 262
            ||:: .:|.:||:.::||::|.|.:||.||||.:.||..|.:::   |.:..||:::.:..|...
Human   208 ILLLSFMPNSPRFLLSRGRDEEALRALAWLRGTDVDVHWEFEQI---QDNVRRQSSRVSWAEARA 269

  Fly   263 RNNLKPLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDSNLSTIIVGVVNFFATFMGIILID 327
            .:..:|::::|.:...||.:||..::.|...||......:.......|||.|...:..:..:.:|
Human   270 PHVCRPITVALLMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLIAALTMD 334

  Fly   328 RLGRKILLYVSDIAMIVTLSILGGFFYCKAHGP-------------------------DVSHLGW 367
            ..|||:||:||...|......||.:.:   .||                         ...:|..
Human   335 LAGRKVLLFVSAAIMFAANLTLGLYIH---FGPRPLSPNSTAGLESESWGDLAQPLAAPAGYLTL 396

  Fly   368 LPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTVAMGA 432
            :||...:::|:|:::|:|||.||:|.|:||.:.||.|:.:....:|...||:||:|..:....|.
Human   397 VPLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPVVSTFGL 461

  Fly   433 HGAFWLFGAICIVGLFFVIIFVPETRGKSLEEIE 466
            ...|:.|.|||:|.|.|....||||:|:|||:||
Human   462 QVPFFFFAAICLVSLVFTGCCVPETKGRSLEQIE 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	150/462 (32%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	139/446 (31%)
SLC2A6	NP_060055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		4/13 (31%)
		Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS_GLUT6_Class3	39..493	CDD:340992	148/460 (32%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	286..292		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144253
Domainoid	1	1.000	301	1.000	Domainoid score	I1411
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2630
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		mtm8509
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760