DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-2 and slc2a5

DIOPT Version :9

Sequence 1:	NP_610694.1	Gene:	Tret1-2 / 36249	FlyBaseID:	FBgn0033644	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001352581.1	Gene:	slc2a5 / 100006415	ZFINID:	ZDB-GENE-060222-2	Length:	511	Species:	Danio rerio

Alignment Length:	480	Identity:	139/480 - (28%)
Similarity:	233/480 - (48%)	Gaps:	67/480 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LSVSLCSLVVGFVSAY---------TSPA--------------LVSMTDRTIT-SFEVTKDAGSW 73
            |.::..|||.||.|::         .|||              ...|:|..:| .:.||.
Zfish    18 LILAAASLVAGFGSSFQYGYNVAVVNSPAPEMQQFYRRIYVDRYGPMSDNLLTLLWSVTV----- 77

  Fly    74 VGGIMPLAALAGGITGGPLIEYLGRRSTILATAVPFIVSSLLIA---CAVNVIMILCGRFLTGFC 135
              .:.||....|.:...||:...||:.|:|...:..||.::::.   .|.:..:|:..|||.|.|
Zfish    78 --SMYPLGGFFGSLMVAPLVNKFGRKGTLLFNNIFSIVPAIMMGVSEVAGSFEIIIVARFLVGIC 140

  Fly   136 VGIASLSLPVYLGETLQPEVRGTLGLLPTALGNIGILVCY------VAGSFMNWS-MLAFLGAAL 193
            .|::|..:|:||||......||.:|::|.....:||||..      :.|:...|. ||...|...
Zfish   141 AGLSSNVVPMYLGEIAPKNYRGAVGIVPQLFITVGILVAQIFGIRSILGNKEGWPIMLGLTGIPA 205

  Fly   194 PVPFLILMIIIPETPRW-FVNRGQEERARKALKWLRGKEADVEPELKELMQSQADADRQATQNTC 257
            .:. |:|:...||:||: .:.:|.|:.|||.|:.|||.| ||:.||.| |:.:..::|...:.:.
Zfish   206 AIE-LLLLPFFPESPRYMLIQKGDEKTARKGLQRLRGCE-DVDEELCE-MRVEEQSERAEGRLSL 267

  Fly   258 LELFKRNNLKPLSISLGLM-FFQQFSGINAVIFYTVQIFKDAGSTIDS-NLSTIIVGVVNFFATF 320
            |.||...:|:...:|:..| ..||.||:||:.:|...|:..||.:.|. ...|:..|.||.|.|.
Zfish   268 LNLFTFRSLRWQLLSVIFMNMGQQLSGVNAIYYYADSIYSSAGVSEDHVQYVTVGTGAVNVFMTI 332

  Fly   321 MGIILIDRLGRKILLYVS-----DIAMIVTLSILGGFFYCKAHGPDVSHLGWLP---LTCFVIYI 377
            ..:.::::.|||:||.:.     ...:|:|:::   :|.        :.|.|:|   :.|.::|:
Zfish   333 TAVFIVEKSGRKLLLLIGFGICCAACVILTIAL---YFQ--------TTLDWIPYVSIVCVIVYV 386

  Fly   378 LGFSLGFGPIPWLMMGEILPAKIRGPAASVVTAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAI 442
            :|.::|..|||.::..|:.....|.||..|..:.:|...|.|...|..|...:|.: :|.:|..|
Zfish   387 IGHAIGPSPIPTVITTEMFRQSSRPPAFMVAGSVHWLSNFTVGLVFPFLERGLGPY-SFIIFACI 450

  Fly   443 CIVGLFFVIIFVPETRGKSLEEIER 467
            |:..|.::.|.:|||:.|:..|..:
Zfish   451 CLATLIYIWIVIPETKNKTFLETSK 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-2	NP_610694.1	Sugar_tr	31..467	CDD:278511	139/478 (29%)
Tret1-2	NP_610694.1	MFS	33..454	CDD:119392	134/465 (29%)
slc2a5	NP_001352581.1	Sugar_tr	23..477	CDD:306568	138/475 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R490
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840