DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-1 and HXT14

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_014081.1	Gene:	HXT14 / 855398	SGDID:	S000005262	Length:	540	Species:	Saccharomyces cerevisiae

Alignment Length:	550	Identity:	121/550 - (22%)
Similarity:	235/550 - (42%)	Gaps:	95/550 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 YEMDEMDNKRGENIRHAVPFVRQITEDGKPKLE-VYRPTTNPIYIWTQVLAALSVSLGSLVVGFV 413
            :..:|:|..||.:....:.::    :|.:..:| .....::...:...||..|.:|||    ||:
Yeast    17 FHNNELDAGRGRDYNVTIKYL----DDKEENIEGQAAKISHNASLHIPVLLCLVISLG----GFI 73

  Fly   414 SAYTSPALVSMTDRNITSFE--------VTQDAGSWV----------GGIMPLAGLAGGIAG--- 457
            ..:....:..||  |:.||:        :..|...:|          |.|:.:..::.|:..
Yeast    74 FGWDIGTIGGMT--NMVSFQEKFGTTNIIHDDETIFVSTKKLTDLQIGLIISIFNISCGVGALTL 136

  Fly   458 GPLIEYLGRRNTILATAVPFIVS-SLLIACAVNVAMVLCGRFLAGFCVGIASLSLPVYLGETVQP 521
            ..:.:::||:..|....|.:.:. ::.|........:..||.:.|..||:.::.:|::|.|....
Yeast   137 SKIGDWIGRKGGIWFALVVYCIGITIQILSYGRWYFLTLGRAVTGIGVGVTTVLVPMFLSENSPL 201

  Fly   522 EVRGTLGLLPTAFGNIGILLCFVAGSFMN---------------WSMLAFLGAALPVPFLILMFL 571
            ::||::..........|||:    |:.:|               |.:..|||....:...:.:..
Yeast   202 KIRGSMVSTYQLIVTFGILM----GNILNFICERCYKDPTQNIAWQLPLFLGYIWAIIIGMSLVY 262

  Fly   572 IPETPRWFVGRGLEERARK----ALKWLRGKEADVEPELKGLMRSQADADRQASRNTMLELLKLN 632
            :||:|::......:..:.|    .:..:...::.|...:..|:.:..:.:...:.:....|:|.|
Yeast   263 VPESPQYLAKIKNDVPSAKYSFARMNGIPATDSMVIEFIDDLLENNYNNEETNNESKKQSLVKRN 327

  Fly   633 NL-----KP-----LSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDGNLCTIIVGIVNFLAT 687
            ..     ||     |.|.:.:|.|||.||||...:|...:||..|.. |..:.:||:..||||:|
Yeast   328 TFEFIMGKPKLWLRLIIGMMIMAFQQLSGINYFFYYGTSVFKGVGIK-DPYITSIILSSVNFLST 391

  Fly   688 FIGIVLIDRAGRK-ILLYVSDIAMVLTLFVLGGFFYCKTYG--------PDVSHLGWLPLTCFVI 743
            .:||..:::.|.| .|||.|...:          ||..||.        .|.|::..:.:||  .
Yeast   392 ILGIYYVEKWGHKTCLLYGSTNLL----------FYMMTYATVGTFGRETDFSNIVLIIVTC--C 444

  Fly   744 YILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAF---W 805
            :|..|::..||:.::::.|:.|.:.|..:.::.|..||...|:::.    ||..:.:...|   :
Yeast   445 FIFWFAITLGPVTFVLVSELFPLRTRAISMAICTFINWMFNFLISL----LTPMIVSKIDFKLGY 505

  Fly   806 LFGAICFVGLFFVIIYVPETQGKTLEDIER 835
            :|.|.....:.|..|.||||:.|..::|.:
Yeast   506 IFAACLLALIIFSWILVPETRKKNEQEINK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	115/514 (22%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	107/483 (22%)
HXT14	NP_014081.1	MFS_HXT	62..537	CDD:340914	114/500 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	4	3.710