DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-1 and HXT2

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_013724.1	Gene:	HXT2 / 855023	SGDID:	S000004613	Length:	541	Species:	Saccharomyces cerevisiae

Alignment Length:	559	Identity:	133/559 - (23%)
Similarity:	235/559 - (42%)	Gaps:	70/559 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 DFLTSR-QHFQQQRSISTDSRKSRRLYEMDEMDNKRGENIRHAVPFVRQITEDGKPKLEVYRPTT 388
            :|.||| :...||.||                         |:.|.|:::..|..| ::.....|
Yeast     3 EFATSRVESGSQQTSI-------------------------HSTPIVQKLETDESP-IQTKSEYT 41

  Fly   389 N------PI-YIWTQVLAALSVSLGSLVVGFVSAYTSPALVSMTDRNITSFEVTQDAGSWVG--- 443
            |      || ..||.:...|.::.|..|.|:.:. |....|:.||......::..|...::.
Yeast    42 NAELPAKPIAAYWTVICLCLMIAFGGFVFGWDTG-TISGFVNQTDFKRRFGQMKSDGTYYLSDVR 105

  Fly   444 -----GIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLL-IACAVNVAMVLCGRFLAGF 502
                 ||..:....||:..|.|.:..|||..::...:.:||..:: ||.:........||.::|.
Yeast   106 TGLIVGIFNIGCAFGGLTLGRLGDMYGRRIGLMCVVLVYIVGIVIQIASSDKWYQYFIGRIISGM 170

  Fly   503 CV-GIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVA-------GSFMNWSMLAFLGA 559
            .| |||.|| |..:.||....:|||..........:||.|.:..       .:.:.|.:...|..
Yeast   171 GVGGIAVLS-PTLISETAPKHIRGTCVSFYQLMITLGIFLGYCTNYGTKDYSNSVQWRVPLGLNF 234

  Fly   560 ALPVPFLILMFLIPETPRWFVGRGLEERARKALKWLRGKEADVE-----PELKGLMRSQADADRQ 619
            |..:..:..|.::||:||:.|.:|..|.|:::|  .:..:..:|     .|:..:| :..:.:|.
Yeast   235 AFAIFMIAGMLMVPESPRFLVEKGRYEDAKRSL--AKSNKVTIEDPSIVAEMDTIM-ANVETERL 296

  Fly   620 ASRNTMLELLKLNNLKPLSISLGLMF--FQQFSGINAVIFYTVQIFKDAGSTIDGNLCTIIVGIV 682
            |...:..||..........:.:|:|.  .||.:|.|...:|...||...|.. |....:|::|||
Yeast   297 AGNASWGELFSNKGAILPRVIMGIMIQSLQQLTGNNYFFYYGTTIFNAVGMK-DSFQTSIVLGIV 360

  Fly   683 NFLATFIGIVLIDRAGRKILLYVSDIAMVLTLFVLGGFFYCKTY-----GPDVSHLGWLPLTCFV 742
            ||.:||:.:..:|:.||:..|.....:|.:...:.........|     .|.....|.:.:....
Yeast   361 NFASTFVALYTVDKFGRRKCLLGGSASMAICFVIFSTVGVTSLYPNGKDQPSSKAAGNVMIVFTC 425

  Fly   743 IYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLF 807
            ::|..|::.:.||.::::.|..|.:::..|.::|...||...|::......:|.|:|....:...
Yeast   426 LFIFFFAISWAPIAYVIVAESYPLRVKNRAMAIAVGANWIWGFLIGFFTPFITSAIGFSYGYVFM 490

  Fly   808 GAICFVGLFFVIIYVPETQGKTLEDIERKMMGRVRRMSS 846
            |.:.| ..|:|..:|.||:|.|||::....:..|:...|
Yeast   491 GCLVF-SFFYVFFFVCETKGLTLEEVNEMYVEGVKPWKS 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	118/486 (24%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	105/449 (23%)
HXT2	NP_013724.1	Sugar_tr	59..519	CDD:395036	112/466 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342792
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13432
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	6	5.640