DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-1 and AMF1

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_015023.1	Gene:	AMF1 / 854560	SGDID:	S000005905	Length:	515	Species:	Saccharomyces cerevisiae

Alignment Length:	576	Identity:	120/576 - (20%)
Similarity:	182/576 - (31%)	Gaps:	211/576 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 EDGKPKLEVYRPTTNPIYIWTQVL--AALSVSLGSL-VVGFVSAYTSPALVSMTDRNITSFEVTQ 436
            :|.:||..::......:....|::  |.|..||..| ::|                  .||..|
Yeast    32 QDERPKSLLWESAFVGVLCSAQLMTQAGLGQSLAPLHIIG------------------NSFGTT- 77

  Fly   437 DAG--SW--------VGGIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIACAV--N 489
            :||  ||        ||..:.:||..|.|.|......||        ...:.:.|||...:|  |
Yeast    78 NAGQLSWFASAYSLTVGTFILIAGRLGDIFGHKKFFVLG--------FFWYALWSLLAGFSVYSN 134

  Fly   490 VAMVLCGRFLAGFCVGIASLSLP---VYLGETVQPEVR--------------------------G 525
            .....|.|...|  :|.|.| ||   ..||.|.:|..|                          |
Yeast   135 QIFFDCCRAFQG--MGPAFL-LPNAIAILGRTYKPGRRKNMVFSLFGASAPGGFFLGAVFSSMLG 196

  Fly   526 TLGLLPTAFGNIGILLCFVAGSFMNWSMLAFLGAALPVPFLILMFLIPETPRWFVGRGLEERARK 590
            .|...|.|:..:|| .|||         ||..|          .|:||.||       :..|...
Yeast   197 QLAWWPWAYWIMGI-ACFV---------LAVAG----------YFVIPHTP-------MPSRDAS 234

  Fly   591 ALKWLRGKEADVEPELKGLMRSQADADRQASRNTMLELLKLN---NLKPL----------SISLG 642
            :.|.|  :..|....:.|                ::.|:..|   |..|:          .:.:|
Yeast   235 SFKLL--ERIDFAGSVTG----------------VVGLILFNFAWNQGPVVGWQTPYTYALLIVG 281

  Fly   643 LMFFQQFSGINAVIFYTVQIFKDAGSTIDGNLCTIIVGIVNFLATFIGIVLI-------DRAGRK 700
            ..|...|:.|.:...:.:..|....|.....|..|..|..:|     ||.:.       |..|:.
Yeast   282 TFFLVIFAYIESRAAFPLLPFAALSSDTAFVLSCIAAGWASF-----GIWIFYTWQFMEDSRGQT 341

  Fly   701 ILLYVSDIAMVLTLFVLGGFFYCKTYGPDVSHLGWLPLTCFVIYILGFSLG-----FGPI----- 755
            .||..:..:.|    .:.||....|.|..:||..  |.|..:..:..|::|     ..|:
Yeast   342 PLLSSAQFSPV----AISGFCAAVTTGFLLSHTP--PSTVMLFAMTAFTVGTILIATAPVHQTYW 400

  Fly   756 ----------PW----------LMMGEILPAKIRGSAAS-VATAFNWFCTFVVTKTFQDLTVAMG 799
                      ||          :|:.:.:|.:.:|.||| |.|..|:           .:::.:|
Yeast   401 AQTFVSIIVMPWGMDMSFPAATIMLSDSMPHEHQGLAASLVNTVVNY-----------SISIGLG 454

  Fly   800 AHGAF------------------WLFG-AICFVGLFFVIIYVPETQGKTLEDIERK 836
            ..|..                  |..| .:..:|:|....|...|..|:.:.|..|
Yeast   455 IAGTIESRVNDGGAKPLKGYRCSWYMGIGLSGLGIFVAATYAWSTFMKSKKRISEK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	115/564 (20%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	110/532 (21%)
AMF1	NP_015023.1	MFS_Amf1_MDR_like	48..493	CDD:341029	112/541 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900