DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-1 and VVS1

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_009800.1	Gene:	VVS1 / 852543	SGDID:	S000000445	Length:	488	Species:	Saccharomyces cerevisiae

Alignment Length:	486	Identity:	138/486 - (28%)
Similarity:	213/486 - (43%)	Gaps:	66/486 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 TNPIYIWTQVLAALSVSLGSLVVGFVSA-------YTSPALVSMTDRNITSFEVTQDAGSWVG-- 443
            |.|:.....:|..:...|||:..|:..|       :.|.:.....|.|| |::.|     |||
Yeast    16 TKPLITGHLILGTIVACLGSIQYGYHIAELNAPQEFLSCSRFEAPDENI-SYDDT-----WVGQH 74

  Fly   444 -----------------GIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIACAVNVA 491
                             .|..:.||.|....|......||:...:..:...:|||||:..:.:..
Yeast    75 GLKQCIALTDSQYGAITSIFSIGGLFGSYYAGNWANRYGRKYVSMGASAMCMVSSLLLFFSNSYL 139

  Fly   492 MVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFV-----AGSFMNW 551
            .:|.||||.|...|.|.:..|:::.|....|.||.:|.:.....|:||||...     |.|: ||
Yeast   140 QLLFGRFLVGMSCGTAIVITPLFINEIAPVEWRGAMGSMNQVSINLGILLTQTLALKYADSY-NW 203

  Fly   552 SMLAFLGAALPVPFLILMFLIPETPRWFVGRGLEERARKALKWLR-GKEADVEPELKGLMRSQA- 614
            ..|.|.|:.:.|..::....:.|:|||.|..|....|..||..|| |.....:.|::...||..
Yeast   204 RWLLFSGSVIAVANILAWLKVDESPRWLVSHGFVSEAETALFKLRPGTYQQAKQEIQDWQRSHGH 268

  Fly   615 DADRQASRNT------MLELLKLNNLKPLSISLGLMFFQQFSGINAVIFYTV----QIFKDAGST 669
            :.|.::|..|      ...:...:..||.::.|.::..|||.|||::|||.|    :|..|....
Yeast   269 NRDPESSEETHSGPTLWQYVTDPSYKKPRTVILAILSCQQFCGINSIIFYGVKVIGKILPDYSIQ 333

  Fly   670 IDGNLCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSDIAM-VLTLFVLGGFFYCKTYGPDVSHL 733
            ::     ..:.|:|.:.|.....:||..||:.||..|...| .::|.:..|.         ...:
Yeast   334 VN-----FAISILNVVVTLAASAIIDHVGRRPLLLASTTVMTAMSLLISVGL---------TLSV 384

  Fly   734 GWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAM 798
            .:|.:|...:||..|::|.||||:|::||:...:...:|.|..|..||..||:|...|......|
Yeast   385 SFLLVTATFVYIAAFAIGLGPIPFLIIGELSYPQDAATAQSFGTVCNWLATFIVGYLFPIGHGLM 449

  Fly   799 GAHGAFWLFGAICFVGLFFVIIYVPETQGKT 829
            |.: .|.:|.||..:...:|...||||:|||
Yeast   450 GGY-VFAIFAAIAAMFATYVYKRVPETKGKT 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	138/486 (28%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	128/464 (28%)
VVS1	NP_009800.1	MFS_GLUT_Class1_2_like	28..478	CDD:340915	132/471 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342643
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2166
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	5	4.770