Protein Alignment Tret1-1 and ITR1

DIOPT Version :10

• Sequence 1: NP_610693.1
• Gene: Tret1-1 / 36248
• FlyBaseID: FBgn0050035
• Length: 857
• Species: Drosophila melanogaster
• Sequence 2: NP_010785.1
• Gene: ITR1 / 852108
• SGDID: S000002905
• Length: 584
• Species: Saccharomyces cerevisiae
• Alignment Length: 618
• Identity: 147/618 - (23%)
• Similarity: 258/618 - (41%)
• Gaps: 109/618 - (17%)

  Fly   301 IHRPKDITKPVIIDLKDLESESDE-DFLTSRQHFQQQRSISTDSRKSRRLYEMDEMDNKRGENIR 364
            ||.|...:|....::.|....:|. :|.:......::..|:.:|.:.:|....|:.|..:.:.:.
Yeast     3 IHIPYLTSKTSQSNVGDAVGNADSVEFNSEHDSPSKRGKITLESHEIQRAPASDDEDRIQIKPVN 67

  Fly   365 HAVPFVRQITEDGKPKLEVYRPTTNPIYIWTQVLAALSVSLGSLVVGFVSAYTSPALVSM---TD 426
                     .||....:..:..:.:|..|....:|::|    ..:.|:.:.|.|.||:|:   .|
Yeast    68 ---------DEDDTSVMITFNQSLSPFIITLTFVASIS----GFMFGYDTGYISSALISIGTDLD 119

  Fly   427 RNITSF---EVTQDAGSWVGGIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIACAV 488
            ..:.::   |:...|.|       |..|...|..|...:..||:..::.:.:.|::.::|...|.
Yeast   120 HKVLTYGEKEIVTAATS-------LGALITSIFAGTAADIFGRKRCLMGSNLMFVIGAILQVSAH 177

  Fly   489 NVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVAGSFMN--- 550
            ....:..||.:.||.|||.||..|:::.|.....:||.|.::.:.:...|.|:.:..|:.:|
Yeast   178 TFWQMAVGRLIMGFGVGIGSLIAPLFISEIAPKMIRGRLTVINSLWLTGGQLVAYGCGAGLNYVN 242

  Fly   551 --WSMLAFLGAALP--VPFLILMFLIPETPRWFVGRGLEERARKALKWLRGKEADVEPELKGLMR 611
              |.:|..| :.:|  |.|..|.|| |:|||::|.:|...||.:.||                 |
Yeast   243 NGWRILVGL-SLIPTAVQFTCLCFL-PDTPRYYVMKGDLARATEVLK-----------------R 288

  Fly   612 SQADADRQASRNTMLELLKLN------------------------NLKPLSISLGLMFFQQFSGI 652
            |..|...:.....:.||:.||                        ||:.|.|..||...|||:|.
Yeast   289 SYTDTSEEIIERKVEELVTLNQSIPGKNVPEKVWNTIKELHTVPSNLRALIIGCGLQAIQQFTGW 353

  Fly   653 NAVIFYTVQIFKDAGSTIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSDIAMVLTLFVL 717
            |::::::..||:..|.. :.:..:|||...||:.|.:....||:.||:.:|.:....|.:.|.|.
Yeast   354 NSLMYFSGTIFETVGFK-NSSAVSIIVSGTNFIFTLVAFFSIDKIGRRTILLIGLPGMTMALVVC 417

  Fly   718 GGFFY----------CKTYGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSA 772
            ...|:          ........|..|.:.:...:::...::||.|.:|| ...|:.|..:||..
Yeast   418 SIAFHFLGIKFDGAVAVVVSSGFSSWGIVIIVFIIVFAAFYALGIGTVPW-QQSELFPQNVRGIG 481

  Fly   773 ASVATAFNWFCTFVVTKTF----QDLTVAMGAHGAFWLFGAICFVGLFFVIIYVPETQGKTLEDI 833
            .|.|||.||..:.|:..||    |::|.|    |.|..|..:..:...|.....||..|..||::
Yeast   482 TSYATATNWAGSLVIASTFLTMLQNITPA----GTFAFFAGLSCLSTIFCYFCYPELSGLELEEV 542

  Fly   834 E-----------RKMMGRVRRMSSVANIKPLSF 855
            :           .|.:.: :|...||.:..|.:
Yeast   543 QTILKDGFNIKASKALAK-KRKQQVARVHELKY 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	MFS_GLUT6_8_Class3_like	397..832	CDD:340916	125/485 (26%)
ITR1	NP_010785.1	MFS_HMIT_like	92..533	CDD:340918	121/476 (25%)