DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-1 and SNF3

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_010087.1	Gene:	SNF3 / 851333	SGDID:	S000002353	Length:	884	Species:	Saccharomyces cerevisiae

Alignment Length:	592	Identity:	139/592 - (23%)
Similarity:	253/592 - (42%)	Gaps:	83/592 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 SESDEDFLTSRQHF-----QQQRSISTDSRKSRRLYEMDEMDNKRGENIRHAVPFVRQITEDGKP 379
            :.|.|.....:|.|     |:.:.|:.....|.:.:..|:...    :||......||.::....
Yeast     6 NSSSETLRQEKQGFLDKALQRVKGIALRRNNSNKDHTTDDTTG----SIRTPTSLQRQNSDRQSN 66

  Fly   380 KLEVYRPTTNPI----YIWTQ------VLAALSVSLGSLVVGFVSAYTSPALVSMTDRNITSFEV 434
            ...|:....:.|    .::::      ::.::.|.:...|.||:..|.:..:.|:|..|.....|
Yeast    67 MTSVFTDDISTIDDNSILFSEPPQKQSMMMSICVGVFVAVGGFLFGYDTGLINSITSMNYVKSHV 131

  Fly   435 TQDAGSWVGGIMPL------AGLAGGIAGGPLI-EYLGRRNTIL-ATAVPFIVSSLLIACAVNVA 491
            ..:..|:....|.:      .|...|....|.| :..||:.||: :|...|.:.:.|...|..:.
Yeast   132 APNHDSFTAQQMSILVSFLSLGTFFGALTAPFISDSYGRKPTIIFSTIFIFSIGNSLQVGAGGIT 196

  Fly   492 MVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRG----------TLGLLPTAFGNIGILLCFVAG 546
            :::.||.::|..:|..|..:|:|..|.....:||          |.|||.::..:.|......|.
Yeast   197 LLIVGRVISGIGIGAISAVVPLYQAEATHKSLRGAIISTYQWAITWGLLVSSAVSQGTHARNDAS 261

  Fly   547 SF-------MNWSMLAFLGAALPVPFLILMFLIPETPRWFVGRGLEERARKALKWLRGKEADVEP 604
            |:       ..||....:|          ||.:||:||::|.:...:.|.|:|.:|||.......
Yeast   262 SYRIPIGLQYVWSSFLAIG----------MFFLPESPRYYVLKDKLDEAAKSLSFLRGVPVHDSG 316

  Fly   605 ELKGLMRSQADADRQAS--RNTMLELLKLNNLKP-----LSISLGLMFFQQFSGINAVIFYTVQI 662
            .|:.|:..:|..|.:||  .:..::....:..:|     :...:.|..||||||||.:.:|.|..
Yeast   317 LLEELVEIKATYDYEASFGSSNFIDCFISSKSRPKQTLRMFTGIALQAFQQFSGINFIFYYGVNF 381

  Fly   663 FKDAGSTIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSDIAMVLTLFVLGGFFYC--KT 725
            |...|.: :..|.:.|...||.:....|:..::..||:.:|.|..:.|.:..|:: ....|  ||
Yeast   382 FNKTGVS-NSYLVSFITYAVNVVFNVPGLFFVEFFGRRKVLVVGGVIMTIANFIV-AIVGCSLKT 444

  Fly   726 YGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWFCTFV---V 787
            .......:.::   |  ::|..||..:|.:.|::..|:.|..:|....::..|.||...|:   :
Yeast   445 VAAAKVMIAFI---C--LFIAAFSATWGGVVWVISAELYPLGVRSKCTAICAAANWLVNFICALI 504

  Fly   788 TKTFQDL---TVAMGAHGAFWLFGAICFVGLFFVIIYVPETQGKTLEDIERKMMGRVRRMSSVAN 849
            |....|.   |.::||. .|:::|::..:|:..|.:.|.||:|.|||:|:...:     .||...
Yeast   505 TPYIVDTGSHTSSLGAK-IFFIWGSLNAMGVIVVYLTVYETKGLTLEEIDELYI-----KSSTGV 563

  Fly   850 IKPLSFN 856
            :.| .||
Yeast   564 VSP-KFN 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	121/500 (24%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	112/460 (24%)
SNF3	NP_010087.1	MFS_HXT	99..556	CDD:340914	120/474 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13432
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	6	5.640