DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-1 and YDL199C

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_010082.1	Gene:	YDL199C / 851328	SGDID:	S000002358	Length:	687	Species:	Saccharomyces cerevisiae

Alignment Length:	596	Identity:	124/596 - (20%)
Similarity:	218/596 - (36%)	Gaps:	145/596 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 KDLESESDEDFLTSRQH-----FQQQRSISTDSRKSRRLYEMDEMDNKRGENIRHAVPFVRQITE 375
            :|..|:.|:..|||..|     |:.:.:|:..|.:...||        |..:....:|.     .
Yeast    32 QDFNSKQDDTALTSLPHKNPDIFRFENNITAHSSRRGSLY--------RDSDATVVLPL-----S 83

  Fly   376 DGKPKLEVYRPTTNPIYIWTQVLAALSVS-LGS---------LVVGFVSAYTSPALVSMTDRNIT 430
            :..|:|.:..|       :.|:|....:| |.|         |...|:|.....:.:|..|:.:.
Yeast    84 EHTPRLSMDDP-------YRQLLQQAEISQLRSKKKRHSSRVLRTSFISFVVLVSSLSGLDQGLI 141

  Fly   431 SFEVT---------QDAGSWVGGIMPLAGLAGGIAG----GPLIEYLGRRNTILATAVPFIVSSL 482
            |..|.         ....|.:|.|:.:..|...:|.    ..::|...|:..:..:.:.:.:.::
Yeast   142 SGNVMTLSFQKYFHYPLTSPLGNIVSIVNLGAFMASLFVYSGILEPCSRKKMLQISTMIYSLGAI 206

  Fly   483 LIACAVNVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVAGS 547
            :...|:|...:|.||||.|..:|.|...:.:|..|...|.:|      .....:|..:...:|.|
Yeast   207 VQVLALNQWCLLLGRFLLGVGMGFAFSMVIIYQFEFPLPCIR------KRTLISIQCVSSVIAYS 265

  Fly   548 FMNWSMLAF--LGAALPVPF-----------LILMFLIPETPRWFVGRGLEERARKALKWLRGKE 599
            |..|...||  ||.|...|.           |:..:||.|:|                .||..::
Yeast   266 FGIWINCAFRYLGFAWRYPLSTHVALGIILNLMSFYLILESP----------------SWLLKQK 314

  Fly   600 ADVEPELKGLMRSQADADRQASRNTMLE--------LLKLN---NLKP-----------LSISLG 642
            .|||..:  |:.:..|........|.|:        |||.:   |..|           :.:.:|
Yeast   315 NDVEALV--LISNVFDDGNFEENQTQLKFRVLKRDILLKSHLQKNSYPYAYILKDFSSIIKLLIG 377

  Fly   643 LMFFQQFSGINAVIFYTVQIFKDAG-----STIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKIL 702
            .....:.:|::|.::|:..|.:..|     |.....|..:|..||  :..::.:||..|. .|..
Yeast   378 FQLLTRTNGVDAFLYYSPLILQQMGRGERKSIYLTGLNALIYSIV--ILAYVPLVLRKRK-EKTN 439

  Fly   703 LYVSDIAMVLTLFVLGGFFYCKTYGPDVSHLGWLPLT-------CFVIYILGFSLGFGPIPWLMM 760
            :.:..|.|...||.             :|...|.|.:       .|.:::....:.:..|.|:|.
Yeast   440 VLLGSIVMCALLFT-------------ISFTDWFPKSTTRYISILFAVFLFTHFISWDSIGWVMT 491

  Fly   761 GEILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAI----CFVGLFFVI-I 820
            .|:||...:.....:.:.|.|     :.|.|..|...:......|.|..|    .|:.:.||: |
Yeast   492 IELLPHLSQAPVILLVSNFYW-----IFKWFVSLITPILIDRLSWKFYLIPSLSSFISIIFVLKI 551

  Fly   821 YVPETQGKTLE 831
            :..||:.:.|:
Yeast   552 FPIETRDERLD 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	108/525 (21%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	102/495 (21%)
YDL199C	NP_010082.1	MFS	122..566	CDD:421695	101/486 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900