DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-1 and GAL2

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_013182.1	Gene:	GAL2 / 850770	SGDID:	S000004071	Length:	574	Species:	Saccharomyces cerevisiae

Alignment Length:	578	Identity:	138/578 - (23%)
Similarity:	242/578 - (41%)	Gaps:	108/578 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 PVIIDLKDLESESDEDFLTSRQHFQQQRSISTDSRKSRRLYEMDEMD-NKRGENIRHAVPFVRQI 373
            ||:    ..:.::.||.::|   ..:...:|..|:|    |..||:. .:.|.....:||    |
Yeast     9 PVV----SQQPQAGEDVISS---LSKDSHLSAQSQK----YSNDELKAGESGSEGSQSVP----I 58

  Fly   374 TEDGKPKLEVYRPTTNPIYIWTQVLAALSVSLGSLVVGFVSAYTSPALVSMTDRNITSFEVTQDA 438
            ....||..|         |: |..|..|.|:.|..:.|:.:. |....|..|| .:..|.:....
Yeast    59 EIPKKPMSE---------YV-TVSLLCLCVAFGGFMFGWDTG-TISGFVVQTD-FLRRFGMKHKD 111

  Fly   439 GSW------VGGIMPLAGLA---GGI---AGGPLIEYLGRRNTILATAVPFIVSSLLIACAVNVA 491
            |:.      .|.|:.:..:.   |||   .||   :..||:.     .:..:||..::...:.:|
Yeast   112 GTHYLSNVRTGLIVAIFNIGCAFGGIILSKGG---DMYGRKK-----GLSIVVSVYIVGIIIQIA 168

  Fly   492 MV------LCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTL----GLLPTAFGNIGILLCFVAG 546
            .:      ..||.::|..||..::..|:.:.|.....:||||    .|:.||...:|....:...
Yeast   169 SINKWYQYFIGRIISGLGVGGIAVLCPMLISEIAPKHLRGTLVSCYQLMITAGIFLGYCTNYGTK 233

  Fly   547 SFMN-------------WSMLAFLGAALPVPFLILMFLIPETPRWFVGRGLEERARKALKWLRGK 598
            |:.|             || |..:||         :.|:||:||:.......|.|::::    .|
Yeast   234 SYSNSVQWRVPLGLCFAWS-LFMIGA---------LTLVPESPRYLCEVNKVEDAKRSI----AK 284

  Fly   599 EADVEPELKG------LMRSQADADRQASRNTMLELL--KLNNLKPLSISLGLMFFQQFSGINAV 655
            ...|.||...      |:.:..:|::.|...:..||.  |....:.|.:.:.:..|||.:|.|..
Yeast   285 SNKVSPEDPAVQAELDLIMAGIEAEKLAGNASWGELFSTKTKVFQRLLMGVFVQMFQQLTGNNYF 349

  Fly   656 IFYTVQIFKDAGSTIDGNLCT-IIVGIVNFLATFIGIVLIDRAGRKILLYVSDIAMVLTLFVLGG 719
            .:|...|||..|  :|.:..| |::|:|||.:||..:..::..|.:..|.:....|:..:.:...
Yeast   350 FYYGTVIFKSVG--LDDSFETSIVIGVVNFASTFFSLWTVENLGHRKCLLLGAATMMACMVIYAS 412

  Fly   720 FFYCKTY-----GPDVSHLG--WLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSAASVAT 777
            ....:.|     .|.....|  .:..|||  ||..::..:.|:.|::..|..|.:::....::|:
Yeast   413 VGVTRLYPHGKSQPSSKGAGNCMIVFTCF--YIFCYATTWAPVAWVITAESFPLRVKSKCMALAS 475

  Fly   778 AFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLFF-VIIYVPETQGKTLEDIE 834
            |.||...|::......:|.|:..:..:...|  |.|.:|| |..:||||:|.:||:|:
Yeast   476 ASNWVWGFLIAFFTPFITSAINFYYGYVFMG--CLVAMFFYVFFFVPETKGLSLEEIQ 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	120/502 (24%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	109/472 (23%)
GAL2	NP_013182.1	Sugar_tr	74..534	CDD:278511	117/488 (24%)
GAL2	NP_013182.1	MFS	75..518	CDD:119392	109/472 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13432
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	6	5.640