DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-1 and HXT10

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_116644.1	Gene:	HXT10 / 850536	SGDID:	S000001883	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	538	Identity:	124/538 - (23%)
Similarity:	232/538 - (43%)	Gaps:	55/538 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 ISTDSRKSRRLYEMDEMDNKRGENIRHAVPFVRQITEDGKPKLEV-YRPTTNPIYIWTQVLAALS 402
            :.|.::.|..|...||               ::...|..:..|:: |:|.   |..||.:...|.
Yeast     9 LGTSAKASTSLSRKDE---------------IKLTPETREASLDIPYKPI---IAYWTVMGLCLM 55

  Fly   403 VSLGSLVVGFVSAYTSPALVSMTD--------RNITSFEVTQDAGSWVGGIMPLAGLAGGIAGGP 459
            ::.|..:.|:.:. |....::.||        :...||:::......:.||..:....||:..|.
Yeast    56 IAFGGFIFGWDTG-TISGFINQTDFKRRFGELQRDGSFQLSDVRTGLIVGIFNIGCALGGLTLGR 119

  Fly   460 LIEYLGRRNTILATAVPFIVSSLL-IACAVNVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEV 523
            |.:..||:..::...:.::|..:: ||.:........||.::|..||..::..|..:.|.....:
Yeast   120 LGDIYGRKIGLMCVILVYVVGIVIQIASSDKWYQYFIGRIVSGMGVGGVAVLSPTLISEISPKHL 184

  Fly   524 RGTLGLLPTAFGNIGILLCFVA-------GSFMNWSMLAFLGAALPVPFLILMFLIPETPRWFVG 581
            |||..........:||.|.:..       .:.:.|.:...|..|..:..:|.|.::||:||:.|.
Yeast   185 RGTCVSFYQLMITLGIFLGYCTNYGTKKYSNSIQWRVPLGLCFAWAIFMVIGMVMVPESPRYLVE 249

  Fly   582 RGLEERARKALKWLRGKEADVEP----ELKGLMRSQADADRQASRNTMLELLKLNNLKPLSISLG 642
            :|..|.||::|. ...|....:|    |...:: :..:.:|.....:..||..........:.:|
Yeast   250 KGKYEEARRSLA-KSNKVTVTDPGVVFEFDTIV-ANMELERAVGNASWHELFSNKGAILPRVIMG 312

  Fly   643 LMF--FQQFSGINAVIFYTVQIFKDAGSTIDGNLCTIIVGIVNFLATFIGIVLIDRAG-RKILLY 704
            ::.  .||.:|.|...:|...||...|.. |....:|::|.|||.:||:.:.::|:.| ||.||:
Yeast   313 IVIQSLQQLTGCNYFFYYGTTIFNAVGMQ-DSFETSIVLGAVNFASTFVALYIVDKFGRRKCLLW 376

  Fly   705 VS-DIAMVLTLFVLGGFFYCKTYG---PDVSHLG--WLPLTCFVIYILGFSLGFGPIPWLMMGEI 763
            .| .:|:...:|...|.......|   |.....|  .:..|||  :|..|::.:.||.::::.|.
Yeast   377 GSASMAICFVIFATVGVTRLWPQGKDQPSSQSAGNVMIVFTCF--FIFSFAITWAPIAYVIVAET 439

  Fly   764 LPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLFFVIIYVPETQGK 828
            .|.:::..|.::|...||...|::......:|.::|....:...|.:.| ..|:|..:|.||:|.
Yeast   440 YPLRVKNRAMAIAVGANWMWGFLIGFFTPFITRSIGFSYGYVFMGCLIF-SYFYVFFFVCETKGL 503

  Fly   829 TLEDIERKMMGRVRRMSS 846
            |||::......|::...|
Yeast   504 TLEEVNEMYEERIKPWKS 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	115/480 (24%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	103/449 (23%)
HXT10	NP_116644.1	Sugar_tr	52..512	CDD:395036	110/466 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13432
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
TreeFam	0	0.000	Not matched by this tool.
	6	5.640