DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-1 and ERD6

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_001031006.1	Gene:	ERD6 / 837414	AraportID:	AT1G08930	Length:	496	Species:	Arabidopsis thaliana

Alignment Length:	552	Identity:	159/552 - (28%)
Similarity:	263/552 - (47%)	Gaps:	66/552 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 IHRPKDITKPVI---IDLKDLESESDEDFLTSRQHFQQQRSISTDSRKSRRLYEMDEMDNKRGEN 362
            :.|.|.:.|.::   :.:::.:..:::.||.|..           ||||.|       :.|:.:|
plant     1 MERQKSMEKGLLRKSLSIRERKFPNEDAFLESGL-----------SRKSPR-------EVKKPQN 47

  Fly   363 IRHAVPFVRQITEDGKPKLEVYRPTTNPIYIWTQVLAALSVSLGSLVVGFVSAYTSPALVSMT-D 426
                        :||:.::      |..:::.|.|..:     ||...|....::|.|...:| |
plant    48 ------------DDGECRV------TASVFLSTFVAVS-----GSFCTGCGVGFSSGAQAGITKD 89

  Fly   427 RNITSFEVTQDAGSWVGGIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIACAVNVA 491
            .:::..|.     |..|.|:.|.||.|.:..|.:.:.|||:.|:|......|...|.:|.|.|..
plant    90 LSLSVAEY-----SMFGSILTLGGLIGAVFSGKVADVLGRKRTMLFCEFFCITGWLCVALAQNAM 149

  Fly   492 MVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVAGSFMNWSMLAF 556
            .:.|||.|.|..|||.|..:|||:.|.....|||:.........|.||.|.|:.|:|:.|.:|..
plant   150 WLDCGRLLLGIGVGIFSYVIPVYIAEIAPKHVRGSFVFANQLMQNCGISLFFIIGNFIPWRLLTV 214

  Fly   557 LGAALPVPFLILMFLIPETPRWFVGRGLEERARKALKWLRGKEADVEPELKGLMRSQADADRQAS 621
            :|....|..:..:|.|||:|||....|.::..|.:|:.|||.:.|:..| ...:|...|......
plant   215 VGLVPCVFHVFCLFFIPESPRWLAKLGRDKECRSSLQRLRGSDVDISRE-ANTIRDTIDMTENGG 278

  Fly   622 RNTMLELLKLNNLKPLSISLGLMFFQQFSGINAVIFYTVQIFKDAG--STIDGNLCTIIVGIVNF 684
            ...|.||.:.....||.|.:||||.||..|.:.|.:|...:|...|  |.|..::...|:.....
plant   279 ETKMSELFQRRYAYPLIIGVGLMFLQQLCGSSGVTYYASSLFNKGGFPSAIGTSVIATIMVPKAM 343

  Fly   685 LATFIGIVLIDRAGRKILLYVSDIAMVLTLFVLGGFFYCKTYG--PDVSHLGWLPLTCFVI--YI 745
            |||    ||:|:.||:.||..|..||.|:..:|...:..:::|  |:::.:    .||..:  :|
plant   344 LAT----VLVDKMGRRTLLMASCSAMGLSALLLSVSYGFQSFGILPELTPI----FTCIGVLGHI 400

  Fly   746 LGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAI 810
            :.|::|.|.:||::|.||.|..::.||.::.|..||...:::|.|| :..:...|.|.|.:|..:
plant   401 VSFAMGMGGLPWIIMAEIFPMNVKVSAGTLVTVTNWLFGWIITYTF-NFMLEWNASGMFLIFSMV 464

  Fly   811 CFVGLFFVIIYVPETQGKTLEDIERKMMGRVR 842
            ....:.|:...||||:|::||:|:..:...|:
plant   465 SASSIVFIYFLVPETKGRSLEEIQALLNNSVQ 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	142/457 (31%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	132/427 (31%)
ERD6	NP_001031006.1	MFS_GLUT6_8_Class3_like	59..486	CDD:340916	140/446 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	292	1.000	Domainoid score	I356
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I822
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		mtm972
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930