Protein Alignment Tret1-1 and SLC2A4

DIOPT Version :9

• Sequence 1: NP_610693.1
• Gene: Tret1-1 / 36248
• FlyBaseID: FBgn0050035
• Length: 857
• Species: Drosophila melanogaster
• Sequence 2: NP_001033.1
• Gene: SLC2A4 / 6517
• HGNCID: 11009
• Length: 509
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 157/508 - (30%)
• Similarity: 238/508 - (46%)
• Gaps: 86/508 - (16%)

  Fly   374 TEDGKPKLEVYRPTTNPIYIWTQVLAALSVSLGSLVVGF-VSAYTSPALVSMTDRNITSFEVTQD 437
            :|||:|..:  |.|      .|.|||..|..||||..|: :....:|..|.....|.|
Human    10 SEDGEPPQQ--RVT------GTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNET------- 59

  Fly   438 AGSWVG-----------------------GIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIV 479
               |:|                       .|..:.|:......|.:.::|||:..:|...|..::
Human    60 ---WLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVL 121

  Fly   480 SSLLIA---CAVNVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILL 541
            ...|:.   .|.:..|::.||||.|...|:.|..:|:|:||.....:||.||.|......||||:
Human   122 GGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILI 186

  Fly   542 CFVAG--SFMN----WSMLAFLGAALPVPFLILMFLIPETPRW-FVGRGLEERARKALKWLRGKE 599
            ..|.|  |.:.    |.:|..|.....:..|:|:...||:||: ::.:.||..|||:||.|.| .
Human   187 AQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTG-W 250

  Fly   600 ADVEPELKGLMRSQADADRQASRNTMLELLKL----NNLKPLSISLGLMFFQQFSGINAVIFYTV 660
            |||    .|::....|..|:..|...|.||:|    .:.:||.|::.|...||.||||||.:|:.
Human   251 ADV----SGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYST 311

  Fly   661 QIFKDAGSTIDGN--LCTIIVGIVNFLATFIGIVLIDRAGRKILLYVS-------DIAMVLTLFV 716
            .||:.||.   |.  ..||..|:||.:.|.:.::|::||||:.|..:.       .|.|.:.|.:
Human   312 SIFETAGV---GQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLL 373

  Fly   717 LGGFFYCKTYGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNW 781
            |...       |.:|::..:.:..||.:   |.:|.|||||.::.|:.....|.:|.:||...||
Human   374 LERV-------PAMSYVSIVAIFGFVAF---FEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNW 428

  Fly   782 FCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLF-FVIIYVPETQGKTLEDI 833
            ...|::...||.:..|||.: .|.|| |:..:|.| |..:.||||:|:|.:.|
Human   429 TSNFIIGMGFQYVAEAMGPY-VFLLF-AVLLLGFFIFTFLRVPETRGRTFDQI 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	152/498 (31%)
		MFS	401..822	CDD:119392	140/468 (30%)
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269|PubMed:16647043	7..13		1/2 (50%)
		Sugar_tr	27..483	CDD:306568	148/483 (31%)
		Monosaccharide binding. /evidence=ECO:0000250|UniProtKB:P11166	298..304		4/5 (80%)
		Dileucine internalization motif. /evidence=ECO:0000269|PubMed:8300557	489..490

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144213
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2166
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.770