DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-1 and SLC2A2

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_000331.1	Gene:	SLC2A2 / 6514	HGNCID:	11006	Length:	524	Species:	Homo sapiens

Alignment Length:	545	Identity:	140/545 - (25%)
Similarity:	243/545 - (44%)	Gaps:	94/545 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 HFQQQRSISTDSRKSRRLYEMDEMDNKRGENIRHAVPFVRQITEDGKPKLEVYRPTTNPIYIW-- 394
            |::....:..|.||:...|.::..|.            :..|:....||     ||.     |
Human    41 HYRHVLGVPLDDRKAINNYVINSTDE------------LPTISYSMNPK-----PTP-----WAE 83

  Fly   395 --TQVLAALSVSLGSLVVGFVSAYTSPALVSMTDRNITSFEVTQDAGSWVGGIMPLAGLAGGIAG 457
              |...|.|...|.||                   :::||.|              .|:.....|
Human    84 EETVAAAQLITMLWSL-------------------SVSSFAV--------------GGMTASFFG 115

  Fly   458 GPLIEYLGRRNTILATAVPFIVSSLLIA---CAVNVAMVLCGRFLAGFCVGIASLSLPVYLGETV 519
            |.|.:.|||...:|...:..:|.:||:.   ...:..:::.||.::|...|:.|..:|:|:||..
Human   116 GWLGDTLGRIKAMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIA 180

  Fly   520 QPEVRGTLGLLPTAFGNIGILLC------FVAGSFMNWSMLAFLGAALPVPFLILMFLIPETPRW 578
            ...:||.||.........|||:.      |:.|::..|.:|..|.....:...:|:|..||:||:
Human   181 PTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRY 245

  Fly   579 -FVGRGLEERARKALKWLRGKEADVEPELKGLMRSQADADRQASRNTMLELLKLNNLK-PLSISL 641
             ::....|.:|:::||.|||.: ||..::..:.:.:.:|..: .:.::::|...::.: |:.::|
Human   246 LYIKLDEEVKAKQSLKRLRGYD-DVTKDINEMRKEREEASSE-QKVSIIQLFTNSSYRQPILVAL 308

  Fly   642 GLMFFQQFSGINAVIFYTVQIFKDAGSTIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKIL---- 702
            .|...|||||||.:.:|:..||:.||.: .....||.||.||.:.|.:.:.|:::|||:.|
Human   309 MLHVAQQFSGINGIFYYSTSIFQTAGIS-KPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIG 372

  Fly   703 ---LYVSDIAMVLTLFVLGGFFYCKTYGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEIL 764
               ::|..|.|.:.|.:|..|          |.:.::.:....:::..|.:|.|||||.|:.|..
Human   373 MSGMFVCAIFMSVGLVLLNKF----------SWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFF 427

  Fly   765 PAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLFFVIIYVPETQGKT 829
            ....|.:|.::|...||.|.|:|...||.:....|.: .|:||..:......|....||||:||:
Human   428 SQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPY-VFFLFAGVLLAFTLFTFFKVPETKGKS 491

  Fly   830 LEDIE---RKMMGRVRRMSSVANIK 851
            .|:|.   :|..|...|..:...:|
Human   492 FEEIAAEFQKKSGSAHRPKAAVEMK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	126/472 (27%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	114/438 (26%)
SLC2A2	NP_000331.1	Sugar_tr	14..499	CDD:278511	136/526 (26%)
		MFS	98..485	CDD:119392	112/433 (26%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	314..320		5/5 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144196
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750