DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-1 and SLC2A1

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_006507.2	Gene:	SLC2A1 / 6513	HGNCID:	11005	Length:	492	Species:	Homo sapiens

Alignment Length:	482	Identity:	147/482 - (30%)
Similarity:	229/482 - (47%)	Gaps:	76/482 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 VLAALSVSLGSLVVGFVSAYTSPALVSMTDRNITSFEVTQDAGSWV----GGIMP---------- 447
            :||.....||||..|:     :..:::...:.|..| ..|   :||    ..|:|
Human    13 MLAVGGAVLGSLQFGY-----NTGVINAPQKVIEEF-YNQ---TWVHRYGESILPTTLTTLWSLS 68

  Fly   448 -----LAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIA---CAVNVAMVLCGRFLAGFCV 504
                 :.|:.|..:.|..:...||||::|...:...||::|:.   ...:..|::.|||:.|...
Human    69 VAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYC 133

  Fly   505 GIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVAG--SFMN----WSML---AFLGAA 560
            |:.:..:|:|:||.....:||.||.|......:|||:..|.|  |.|.    |.:|   .|:.|.
Human   134 GLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNKDLWPLLLSIIFIPAL 198

  Fly   561 LPVPFLILMFLIPETPRW-FVGRGLEERARKALKWLRGKEADVEPELKGLMRSQADADRQASRN- 623
            |..  ::|.| .||:||: .:.|..|.||:..||.||| .|||..:|    :...:..||..|.
Human   199 LQC--IVLPF-CPESPRFLLINRNEENRAKSVLKKLRG-TADVTHDL----QEMKEESRQMMREK 255

  Fly   624 --TMLELLKLNNLK-PLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDGNLCTIIVGIVNFL 685
              |:|||.:....: |:.|::.|...||.||||||.:|:..||:.|| .......||..||||..
Human   256 KVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAG-VQQPVYATIGSGIVNTA 319

  Fly   686 ATFIGIVLIDRAGRKILLYVS-------DIAMVLTLFVLGGFFYCKTYGPDVSHLGWLPLTCFVI 743
            .|.:.:.:::||||:.|..:.       .|.|.:.|.:|...       |.:|:|..:.:..||.
Human   320 FTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQL-------PWMSYLSIVAIFGFVA 377

  Fly   744 YILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFG 808
            :   |.:|.|||||.::.|:.....|.:|.:||...||...|:|...||.:....|.: .|.:|.
Human   378 F---FEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPY-VFIIFT 438

  Fly   809 AICFVGLFFVIIY--VPETQGKTLEDI 833
            .:  :.|||:..|  ||||:|:|.::|
Human   439 VL--LVLFFIFTYFKVPETKGRTFDEI 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	146/480 (30%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	138/465 (30%)
SLC2A1	NP_006507.2	MFS_GLUT_Class1	14..458	CDD:340989	144/474 (30%)
		Monosaccharide binding. /evidence=ECO:0000269\|PubMed:24847886	282..288		4/5 (80%)
		Disordered. /evidence=ECO:0000305\|PubMed:30197081	468..492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144179
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2166
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.770