DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-1 and Glut3

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_536732.1	Gene:	Glut3 / 42036	FlyBaseID:	FBgn0015230	Length:	507	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	144/523 - (27%)
Similarity:	230/523 - (43%)	Gaps:	70/523 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 SRKS-----RRLYEMDEMDNKRGENIRHA--VPFVRQITEDGKPKLEVYRPTTNPIYIWTQVLAA 400
            ||||     :|..||.|         ||.  .|..::|...|..|..:|.
  Fly    18 SRKSGTWFAKRPSEMPE---------RHVERAPVRQKINNVGLYKATLYS--------------- 58

  Fly   401 LSVSLGSLVVGFVSAYTSPALVSMTDRNITSFEVTQDAGSWVGGIMPLAGLAGGIAGGPLIEYLG 465
               ::||...|....::..|..|:.:::..||:.|:...|.|..::.|......:..|.::..||
  Fly    59 ---NIGSFFFGIAVGWSGTAERSVMEQHSYSFQPTELQWSGVCILLTLGAALWCLPMGLMVRLLG 120

  Fly   466 RRNTILATAVPFIVSSLLIACAVNVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLL 530
            .|.|||...:|..:...|...|.:|.|:..|||..|.|.|...:.:|:|..|....:.||.:|::
  Fly   121 CRRTILIQLLPNFLGWFLTVFARSVPMLYAGRFFLGMCGGAHCVVVPIYNAEISTTKKRGAMGVV 185

  Fly   531 PTAFGNIGILLCFVAGSFMNWSMLAF--LGAALPVPFLILMFLIPETPRWFVGRGLEERARKALK 593
            .......|::..|....|:...::.|  ||.....|..|||   ||:|.::|..|...||..:|:
  Fly   186 FEGACICGVIYSFAMSLFLELRIINFVNLGLLALGPLQILM---PESPAYYVDHGNIPRAEDSLR 247

  Fly   594 WLRGKEADVEPELKGLMRSQADADRQASRNTMLELLKLNNLKPLSISLGLMFFQQFSGINAVIFY 658
            :|||::.|...|:..|.|...:::|:..:..:|........:.|:.||.:...|:..|....|||
  Fly   248 FLRGQKYDTRREIDFLTRDPTESEREVRQGPLLGFKYKKVRRSLARSLAIALLQKLCGALIFIFY 312

  Fly   659 ------TVQIFKDAGSTIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSDIAMVLTLFVL 717
                  .::|.::.|..    ||..:  |:.|||.|.   |:||.||:.||..|...:|.....|
  Fly   313 GLNMLDCLRIRREFGLI----LCLGL--ILGFLACFF---LVDRLGRRPLLIFSSAGIVFVSIYL 368

  Fly   718 G-GFFYCKTYGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNW 781
            | .|....|.|..|  :.|:.|.|..|::..::.|.|.:.|::..|:|...:|....|:..||||
  Fly   369 GLHFKVWMTMGLTV--MSWIALFCIAIFVGCYTAGVGSLTWVLNAELLVRPMRPLGCSIVCAFNW 431

  Fly   782 FCTFVVTKTFQDLTVAMGAHGA------FWLFGAICFVGLFFVIIYVPETQGKTLEDIERKMMGR 840
            ...|.|...|       |:||.      |.||..|..:.|.|.:||:|||:..:...|::::.|.
  Fly   432 LTAFFVICWF-------GSHGVKCQPYLFLLFAIIASLILLFSLIYIPETKKLSSAKIQQRLGGL 489

  Fly   841 VRR 843
            :.|
  Fly   490 INR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	127/465 (27%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	122/435 (28%)
Glut3	NP_536732.1	Sugar_tr	60..484	CDD:278511	127/444 (29%)
Glut3	NP_536732.1	MFS	63..>226	CDD:119392	41/162 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444383
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4448
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
	8	7.800