DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-1 and CG10960

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_648605.1	Gene:	CG10960 / 39458	FlyBaseID:	FBgn0036316	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	196/522 - (37%)
Similarity:	290/522 - (55%)	Gaps:	23/522 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 QQQRSISTDSRKSRRLYEMDEMDNKRGENIRHAVPFVRQITEDGKPKLE-----------VYRPT 387
            :..:...:::.:|..|.|..|...|.|.  |..|..|: .:::|:....           |:..|
  Fly    13 EANKKSGSNNEESSHLLESAENGAKYGS--RQPVKIVK-ASDNGRTSSTPHDQENLLGNMVHTST 74

  Fly   388 TNPIYIWTQVLAALSVSLGSLVVGFVSAYTSPALVSMTDRNI-TSFEVTQDAGSWVGGIMPLAGL 451
            :|....|.|.:|||:.:.|:...|.|..:||||...:.||.. ..|.|.:|..||||..|.|...
  Fly    75 SNNSQKWPQYVAALAAAGGAFAAGTVLGWTSPAETEIVDRGEGYDFPVDKDQFSWVGSAMTLGAA 139

  Fly   452 AGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIACAVNVAMVLCGRFLAGFCVGIASLSLPVYLG 516
            ...|..|.||..:||:.|:|...:|||:...::..||||:|:...||:.|...|...::.|:|.|
  Fly   140 CVCIPIGFLINMIGRKWTMLFLVLPFILGWTMLIWAVNVSMLYASRFILGIAGGAFCVTAPMYTG 204

  Fly   517 ETVQPEVRGTLGLLPTAFGNIGILLCFVAGSFMNWSMLAFLGAALPVPFLILMFLIPETPRWFVG 581
            |..|.|:|||||........||||..:..|:.:....|:.:...||:.|..:.|.:||:|.:.|.
  Fly   205 EIAQKEIRGTLGSFFQLMITIGILFVYAVGAGVKIFWLSIICGILPLIFGAIFFFMPESPTYLVS 269

  Fly   582 RGLEERARKALKWLRGKEADVEPELKGLMRSQADADRQASRNTMLELLKLN---NLKPLSISLGL 643
            :...|.|.|:::||||||.|.||||..|    .:.||:...|.:.....||   ..|.|:||:||
  Fly   270 KDRSENAIKSIQWLRGKEYDYEPELAEL----RETDRETKANKVNVWAALNRPVTRKALAISMGL 330

  Fly   644 MFFQQFSGINAVIFYTVQIFKDAGSTIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSDI 708
            |||||..||||||||..:||.:|.:.|:....||::||:..:|||:..:::|:.||:|||..|.|
  Fly   331 MFFQQVCGINAVIFYASRIFLEANTGIEAEWATILIGIMQVVATFVSTLVVDKLGRRILLLASGI 395

  Fly   709 AMVLTLFVLGGFFYC-KTYGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSA 772
            :|.::...:|.:|:. |.....|..|||||:....::|:.||:|:||:|||||||:....|:|.|
  Fly   396 SMAISTTAIGVYFFLQKQDAAQVVSLGWLPVASLCLFIIMFSIGYGPVPWLMMGELFATDIKGFA 460

  Fly   773 ASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLFFVIIYVPETQGKTLEDIERKM 837
            .|:|...||...|||||||.:|...:|..|.||||..:..||:.||...||||:||:|.:|::::
  Fly   461 GSLAGTSNWLLAFVVTKTFVNLNDGLGIGGTFWLFAGLTVVGVIFVYFAVPETKGKSLNEIQQEL 525

  Fly   838 MG 839
            .|
  Fly   526 AG 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	184/466 (39%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	170/425 (40%)
CG10960	NP_648605.1	MFS_1	117..474	CDD:284993	142/360 (39%)
CG10960	NP_648605.1	MFS	118..508	CDD:119392	160/393 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444321
Domainoid	1	1.000	212	1.000	Domainoid score	I87
eggNOG	1	0.900	-	-		E1_KOG0254
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I2130
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		mtm8886
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	P	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
	11	10.800