DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-1 and slc2a2

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_001036186.1	Gene:	slc2a2 / 322493	ZFINID:	ZDB-GENE-030131-1213	Length:	504	Species:	Danio rerio

Alignment Length:	498	Identity:	142/498 - (28%)
Similarity:	232/498 - (46%)	Gaps:	91/498 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 TQVLAALSVSLGSLVVGF-------------------VSAY------------------TSPALV 422
            |..||..:.:||||.:|:                   :..|                  |.|::|
Zfish     8 TLALAVFTAALGSLQMGYSLGVINAPQKVIERHYARSLGVYNEDLARSEGGNGTEHEKPTDPSVV 72

  Fly   423 SMTDRNITSFEVTQDAGSWVGGIMP--LAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIA 485
            .....::..|.        |||::.  |....|        ::.||...:||..|..|.:.||:.
Zfish    73 MYWSLSVAIFS--------VGGMLSSFLVSFVG--------DFRGRIKGMLAINVLAITAGLLMG 121

  Fly   486 CA---VNVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGIL------L 541
            .|   ....||:.||.:.|...|::|..:|:|:||....:.||.:|.|......||||      |
Zfish   122 LAKMGTPHLMVIAGRAIMGLYCGLSSGLVPLYIGEISPVKYRGAMGALHQLAIVIGILISQVIGL 186

  Fly   542 CFVAGSFMNWSMLAFLGAALPVPFLILMFLIPETPRW-FVGRGLEERARKALKWLRGKEADVEPE 605
            .|:.|:...|.:|..|..|..:...:|:.:.||:||: ::.:|..|.|.|:||.|:| :.|...:
Zfish   187 DFLLGNDYMWHILLGLSGAPAILQSLLLLVCPESPRYLYIKQGKVEDACKSLKRLKG-DYDTSKD 250

  Fly   606 LKGLMRSQADADRQASRNTMLELLKLNNLK-PLSISLGLMFFQQFSGINAVIFYTVQIFKDAGST 669
            :..:...:.:|.::| :.::|.||:.:..: .|.::|.:.|.||||||||:.:|:..||:.||.
Zfish   251 IAEMKAEKEEAMKEA-KMSILRLLRSSVYRQQLFVALMMHFSQQFSGINAIFYYSTSIFQTAGV- 313

  Fly   670 IDGN--LCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSDIAMVLTLFVLGGFFYCK-------T 725
              |.  ..||.||:||.:.|.:.::::|||||:          .|||..|||...|.       .
Zfish   314 --GQPVYATIGVGVVNIIFTLVSVLMVDRAGRR----------TLTLVGLGGMCCCAVAMTVGLA 366

  Fly   726 YGPDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWFCTFVVTKT 790
            :....|.:.::.:....:::..|.:|.|||||.::.||.....|.:|.::|...||.|.|:|...
Zfish   367 FQGAYSWMSYVSMVAIFMFVSFFEIGPGPIPWFIVAEIFSQGPRPAAIALAGFCNWTCNFIVGMV 431

  Fly   791 FQDLTVAMGAHGAFWLFGAICFVGLFFVIIYVPETQGKTLEDI 833
            |..|....|:: .|.:|..:.|....|:...||||:|||.|:|
Zfish   432 FPYLVSLCGSY-VFIVFAVLLFGFTLFIYFRVPETKGKTFEEI 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	141/496 (28%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	130/479 (27%)
slc2a2	NP_001036186.1	Sugar_tr	12..477	CDD:278511	140/494 (28%)
slc2a2	NP_001036186.1	MFS	76..462	CDD:119392	121/417 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577202
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2166
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.780