DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-1 and Slc2a12

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_001100921.1	Gene:	Slc2a12 / 308028	RGDID:	1310175	Length:	621	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	139/538 - (25%)
Similarity:	235/538 - (43%)	Gaps:	111/538 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 TQVLAALSVSLGSLVVGFVSAYTSPALVSM-TDRNITSFEVTQDAGSWVGGIMPLAGLAGGIAGG 458
            |.|.||:|    .|:||:.....|.||:.: |...:|..|......|.:.|.. ||.|.||:
  Rat    47 TSVTAAIS----GLLVGYELGLISGALLQIRTLLALTCHEQEMVVSSLLIGAF-LASLTGGV--- 103

  Fly   459 PLIEYLGRRNTILATAVPFIVSSLLIACAVNVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEV 523
             ||:..|||.||:.::....:.||::..:::..:::.||...|..:.::|::..||:.|......
  Rat   104 -LIDRYGRRLTIILSSCLLGLGSLVLILSLSYTLLITGRVAIGVSISLSSIATCVYIAEIAPQHR 167

  Fly   524 RGTLGLLPTAFGNIGILLCFVAG-SFMN----WSMLAFLGAALPVPFL--ILMFLIPETPRWFVG 581
            ||.|..|.......|||..:::. :|.|    |..:  .|..:|:..|  |.|:.:|.:||:.|.
  Rat   168 RGLLVSLNELMIVTGILFAYISNYAFANISNGWKYM--FGLVIPLGVLQAIAMYFLPPSPRFLVM 230

  Fly   582 RGLEERARKALKWLRGKEADVEPELKGLMRSQADADRQASRNTMLELLK-LNNLKP-LSISLGLM 644
            :|.||.|.|.|:.|| ..:|...||. |::|....:.|.|   ..:|.: .:|::. :.|.|.|:
  Rat   231 KGQEEAAGKVLRKLR-VISDTAEELT-LIKSSLKDEYQYS---FWDLFRSKDNMRTRILIGLTLV 290

  Fly   645 FFQQFSGINAVIFYTVQIFKDAG--STIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSD 707
            ||.|.:|...::||...:.|..|  |....:|.:..||:|..::|....:|:|..|.|..|.:..
  Rat   291 FFVQTTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPATLLVDHVGSKTFLCIGS 355

  Fly   708 IAMVLTLFVLG--------GFF-YCKTYGP------------------DVSHLG----------- 734
            ..|..:|..:|        .|. .|:::.|                  ..|.||
  Rat   356 SVMAASLLTMGIVNLNINMNFTNICRSHSPLNQSLEELVFYATGNLSVSNSSLGEHLKRVTPYSK 420

  Fly   735 ---------------------------------------------WLPLTCFVIYILGFSLGFGP 754
                                                         ||.|...::|:..||:|.||
  Rat   421 GLFIPLGNGMEPKGEMAFTSLPNAGLSRTDRQGVTDPAVVPAVYKWLSLASLLVYVAAFSIGLGP 485

  Fly   755 IPWLMMGEILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLFFVI 819
            :|||::.||.|..|||.|.::.::.||....:::.||..:|..:|.....:::..:....|.||:
  Rat   486 MPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLSWVCFIYTVMSLTSLAFVV 550

  Fly   820 IYVPETQGKTLEDIERKM 837
            :::|||:|.:||.|..::
  Rat   551 LFIPETKGCSLEQISMEL 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	138/532 (26%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	128/515 (25%)
Slc2a12	NP_001100921.1	MFS_GLUT12_Class3	46..564	CDD:340993	138/532 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337989
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750