DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-1 and itr1

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_593858.2	Gene:	itr1 / 2543145	PomBaseID:	SPAC4F8.15	Length:	575	Species:	Schizosaccharomyces pombe

Alignment Length:	591	Identity:	148/591 - (25%)
Similarity:	251/591 - (42%)	Gaps:	98/591 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 SESDEDF--LTSRQHFQQQRSISTDSRKSRRLYEMDEMDNK-------------------RGENI 363
            |.|.:||  :||........:..|.:...:..:|....:||                   ...||
pombe     2 SISSKDFQNVTSAGFADDTFAADTFAADKKSPFESSVFENKTQVLPVDSVSRLSNGARSRSNSNI 66

  Fly   364 RHAVPF-VRQITEDGKPKLEVYRPTTNPIYIWTQVLAALSVSLGSLVVGFVSAYTSPALVSMTDR 427
            ..:.|. :....||            .|:..|..|| |.:..:|.|:.|:.:...|.||| :...
pombe    67 SLSEPHALNDTVED------------QPVSKWVWVL-AFAAGIGGLLFGYDTGVISGALV-VIGT 117

  Fly   428 NITSFEVTQDAGSWVGGIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIACAVNVAM 492
            ::...|:|.....::.....|..|.|||..|.|.::.||:..|...::..||.|::...|.::..
pombe   118 SLGGHELTNGGKEFITSATSLGALLGGIIAGALADFFGRKPVIAIASIIIIVGSIVQVTAHHLWH 182

  Fly   493 VLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVAGSFM-------- 549
            ::.|||:.|:.||||||.:|:||.|....::||.|.::        .:|...||..:
pombe   183 MIVGRFVIGWGVGIASLIIPLYLSEIAPSKIRGRLVII--------YVLLITAGQVIAYGIDTAF 239

  Fly   550 -----NWSMLAFLGAALPVPF-LILMFLIPETPRWFVGRGLEERARKALKWLRGKEADVEP-ELK 607
                 .|..:..| |.:|..| |.::..:||:||..|.:   ||:::|...|........| |:|
pombe   240 EHVHNGWRWMVGL-AMVPAAFQLFILIWLPESPRLLVKK---ERSQEAYNTLARIYPTAHPYEIK 300

  Fly   608 --------GLMRSQADADRQASRNTMLEL-LKLNNLKPLSISLGLMFFQQFSGINAVIFYTVQIF 663
                    |:....:.:..|....|..|| ...:|.:.|.::.||...||.||.|::::::..||
pombe   301 TKLYLIQEGVRDPFSGSRWQKIVKTFKELYFNPSNFRALILACGLQAMQQLSGFNSLMYFSSTIF 365

  Fly   664 KDAG---STIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSDIAMVLTLFVLGGFFYC-- 723
            :..|   .|..|    :|:...||:.|.:...:||..||:|||.::...|:..|.|....|:.
pombe   366 EVVGFNNPTATG----LIIAATNFVFTIVAFGVIDFFGRRILLLLTVWGMIAALIVCAVAFHFLP 426

  Fly   724 ----KTYGPDVSHLGW--LPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWF 782
                ..|....|: .|  :.|...::|:..::.|.|.:|| ...|:.|..:||....::||.||.
pombe   427 KDENGNYTSGQSN-AWAIVVLISMIVYVASYASGLGNLPW-QQSELFPMSVRGLGTGMSTAVNWA 489

  Fly   783 CTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLFFVIIYVPETQGKTLEDI---------ERKMM 838
            ....:..:|..|...:...|.|.|:|.:||:|....:...|:....|:|:|         .|:.|
pombe   490 GNLGIGASFLTLMSEITPTGTFALYGGLCFLGWLGALFCYPDLTDYTIEEIGELLKHGFGVRESM 554

  Fly   839 GRVRRM 844
            ..::|:
pombe   555 RHLKRV 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	129/485 (27%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	121/455 (27%)
itr1	NP_593858.2	Sugar_tr	90..544	CDD:278511	127/473 (27%)
itr1	NP_593858.2	MFS	92..529	CDD:119392	121/455 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	184	1.000	Inparanoid score	I1095
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13833
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2166
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.890