DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-1 and itr2

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_593320.1	Gene:	itr2 / 2541827	PomBaseID:	SPAC20G8.03	Length:	557	Species:	Schizosaccharomyces pombe

Alignment Length:	606	Identity:	146/606 - (24%)
Similarity:	260/606 - (42%)	Gaps:	121/606 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 PRVTFKLDKVLQGSSTDSDEEGED--AEHKRLIHRPKDITK--PVIIDLKDLESESDEDFLTSRQ 331
            |..|.|          .||::|:|  .|   :..||.:..|  |...|::::.|..:|
pombe     7 PLATIK----------SSDDKGKDFIVE---MTTRPSETKKKVPFSEDMREIPSLPNE------- 51

  Fly   332 HFQQQRSISTDSRKSRRLYEMDEMDNKRGENIRHAVPFVRQITEDGKPKLEVYRPTTNPIYIWTQ 396
                :.:.:||.       :.:|:.::.||...                       ...|..|..
pombe    52 ----EEANATDP-------QANEVADENGEGFE-----------------------AEKISSWIW 82

  Fly   397 VLAALSVSLGSLVVGFVSAYTSPALVSMTDRNITSFEVTQDAGSWVGGIM------------PLA 449
            ||:|:: .:..|:.|:.:...|.||..:              ||.:|.::            ..|
pombe    83 VLSAVA-GISGLLFGYDTGVISGALAVL--------------GSDLGHVLSSGQKELITSATSFA 132

  Fly   450 GLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIACAVNVAMVLCGRFLAGFCVGIASLSLPVY 514
            .|......|.|.:::||:..:|.....|::.|:::|.:.||||::.|||:.|:.:|:.||.:|:|
pombe   133 ALISATTSGWLADWVGRKRLLLCADAIFVIGSVIMAASRNVAMMVVGRFIVGYGIGLTSLIVPMY 197

  Fly   515 LGETVQPEVRGTLGLLPTAFGNIGILLCFVAGS-----FMNWSMLAFLGAALPVPFLILMFLIPE 574
            :.|.....:||.|.::...|...|.|:.:...:     ...|.::..:|||..:..||.:|..||
pombe   198 ITELAPARLRGRLVIIYVVFITGGQLIAYSLNAAFEHVHQGWRIMFGIGAAPALGQLISLFWTPE 262

  Fly   575 TPRWFVGRGLEERARKALKWLRGKEADVEPELK--------GLMRSQADADRQASR--NTMLELL 629
            :||:.:.....|:..|.|       :.:.||.|        .|::.....|.....  ......|
pombe   263 SPRYLLRHNHVEKVYKIL-------SRIHPEAKPAEIAYKVSLIQEGVKVDFPEGNKFQHFFHSL 320

  Fly   630 KL-----NNLKPLSISLGLMFFQQFSGINAVIFYTVQIFKDAG--STIDGNLCTIIVGIVNFLAT 687
            |:     :|.:.|.|...|.:||||||.||:.:::..||:..|  ::|.   .:|:||..||:.|
pombe   321 KVLFTVPSNRRSLFIGCFLQWFQQFSGTNAIQYFSAIIFQSVGFKNSIS---VSIVVGATNFVFT 382

  Fly   688 FIGIVLIDRAGRKILLYVSDIAMVLTLFVLG-GFFYCKTYGPDVSHLGW--LPLTCFVIYILGFS 749
            .:..:.|||.||:.:|..:...|:..|.:.. .:.:........::.||  :.|...:|::..::
pombe   383 IVAFMFIDRIGRRRILLCTSAVMIAGLALCAIAYHFLPADTTQNTNSGWQYVVLASIIIFLASYA 447

  Fly   750 LGFGPIPWLMMGEILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVG 814
            .|.|.||| ...|:.|.::|...|..:||.||....:::.:|..:..::...|.|.||...||||
pombe   448 SGIGNIPW-QQAELFPMEVRALGAGFSTAINWVGNLIISASFLTMMESITPTGTFALFAGFCFVG 511

  Fly   815 LFFVIIYVPETQGKTLEDIER 835
            |.......||..|.::|:|.:
pombe   512 LVTSYFTYPELAGMSIENIHK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	125/487 (26%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	116/457 (25%)
itr2	NP_593320.1	Sugar_tr	84..534	CDD:278511	123/475 (26%)
itr2	NP_593320.1	MFS	86..519	CDD:119392	117/458 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I819
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	184	1.000	Inparanoid score	I1095
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13833
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2166
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.890