DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-1 and Slc2a2

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_037011.2	Gene:	Slc2a2 / 25351	RGDID:	3705	Length:	522	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	141/534 - (26%)
Similarity:	241/534 - (45%)	Gaps:	98/534 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 HFQQQRSISTDSRKSRRLYEMDEMDNKRGENIRHAVPFVRQITEDGKPKLEVYRPTTNPIYIWTQ 396
            |::....:..|.|::...|:::..|........|..|...:...:|...:..        .:|:
  Rat    41 HYRHVLGVPLDDRRATINYDINGTDTPLIVTPAHTTPDAWEEETEGSAHIVT--------MLWS- 96

  Fly   397 VLAALSVSLGSLVVGFVSAYTSPALVSMTDRNITSFEVTQDAGSWVGGIMPLAGLAGGIAGGPLI 461
             |:..|.::|.:|..|.                         |.|:|
  Rat    97 -LSVSSFAVGGMVASFF-------------------------GGWLG------------------ 117

  Fly   462 EYLGRRNTILATAVPFIVSSLLIACA---VNVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEV 523
            :.|||...:||.....:..:||:.|:   ...|:::.||.::|...|:.|..:|:|:||.....:
  Rat   118 DKLGRIKAMLAANSLSLTGALLMGCSKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTL 182

  Fly   524 RGTLGLLPTAFGNIGILLCFVAG-SFM-----NWSMLAFLGAALPVPFL---ILMFLIPETPRWF 579
            ||.||.|.......|||:..:|| ||:     .|.:|..|.|   ||.|   :|:...||:||:.
  Rat   183 RGALGTLHQLALVTGILISQIAGLSFILGNQDYWHILLGLSA---VPALLQCLLLLFCPESPRYL 244

  Fly   580 VGRGLEE--RARKALKWLRGKEADVEPELKGLMRSQADADRQASRNTMLELLKLNNLKPLSISLG 642
            ..: |||  ||:|:||.|||.| ||..::..:.:.:.:|..:...:.:......|..:|:.::|.
  Rat   245 YLK-LEEEVRAKKSLKRLRGTE-DVTKDINEMRKEKEEASTEQKVSVIQLFTDPNYRQPIVVALM 307

  Fly   643 LMFFQQFSGINAVIFYTVQIFKDAGSTIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSD 707
            |...|||||||.:.:|:..||:.||.: .....||.||.:|.:.|.:.::|:::|||:
  Rat   308 LHLAQQFSGINGIFYYSTSIFQTAGIS-QPVYATIGVGAINMIFTAVSVLLVEKAGRR------- 364

  Fly   708 IAMVLTLFVLG--GFFYCKTYG-------PDVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEI 763
                 |||:.|  |.|:|..:.       ...:.:.::.:|...:::..|.:|.|||||.|:.|.
  Rat   365 -----TLFLAGMIGMFFCAVFMSLGLVLLDKFTWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEF 424

  Fly   764 LPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLFFVIIYVPETQGK 828
            .....|.:|.::|...||.|.|::...||.:...:|.: .|:||..:..:...|....||||:||
  Rat   425 FSQGPRPTALALAAFSNWVCNFIIALCFQYIADFLGPY-VFFLFAGVVLIFTLFTFFKVPETKGK 488

  Fly   829 TLEDIE---RKMMG 839
            :.::|.   ||..|
  Rat   489 SFDEIAAEFRKKSG 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	129/473 (27%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	121/443 (27%)
Slc2a2	NP_037011.2	MFS_GLUT_Class1	12..488	CDD:340989	135/518 (26%)
Slc2a2	NP_037011.2	Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	312..318		5/5 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337941
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750