DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-1 and Slc2a1

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_620182.1	Gene:	Slc2a1 / 24778	RGDID:	3704	Length:	492	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	145/482 - (30%)
Similarity:	224/482 - (46%)	Gaps:	76/482 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 VLAALSVSLGSLVVGF-VSAYTSP------------------ALVSMTDRNITSFEVTQDAGSWV 442
            :||.....||||..|: .....:|                  ::.|.|...:.|..|
  Rat    13 MLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGESIPSTTLTTLWSLSV-------- 69

  Fly   443 GGIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIA---CAVNVAMVLCGRFLAGFCV 504
             .|..:.|:.|..:.|..:...||||::|...:...||::|:.   ...:..|::.|||:.|...
  Rat    70 -AIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYC 133

  Fly   505 GIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVAG--SFMN----WSML---AFLGAA 560
            |:.:..:|:|:||.....:||.||.|......:|||:..|.|  |.|.    |.:|   .|:.|.
  Rat   134 GLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPAL 198

  Fly   561 LPVPFLILMFLIPETPRW-FVGRGLEERARKALKWLRGKEADVEPELKGLMRSQADADRQASRN- 623
            |.   .||:...||:||: .:.|..|.||:..||.||| .|||..:|    :...:..||..|.
  Rat   199 LQ---CILLPFCPESPRFLLINRNEENRAKSVLKKLRG-TADVTRDL----QEMKEEGRQMMREK 255

  Fly   624 --TMLELLKLNNLK-PLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDGNLCTIIVGIVNFL 685
              |:|||.:....: |:.|::.|...||.||||||.:|:..||:.|| .......||..||||..
  Rat   256 KVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAG-VQQPVYATIGSGIVNTA 319

  Fly   686 ATFIGIVLIDRAGRKILLYVS-------DIAMVLTLFVLGGFFYCKTYGPDVSHLGWLPLTCFVI 743
            .|.:.:.:::||||:.|..:.       .:.|.:.|.:|...       |.:|:|..:.:..||.
  Rat   320 FTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLEQL-------PWMSYLSIVAIFGFVA 377

  Fly   744 YILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFG 808
            :   |.:|.|||||.::.|:.....|.:|.:||...||...|:|...||.:....|.: .|.:|.
  Rat   378 F---FEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTSNFIVGMCFQYVEQLCGPY-VFIIFT 438

  Fly   809 AICFVGLFFVIIY--VPETQGKTLEDI 833
            .:  :.|||:..|  ||||:|:|.::|
  Rat   439 VL--LVLFFIFTYFKVPETKGRTFDEI 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	144/480 (30%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	136/465 (29%)
Slc2a1	NP_620182.1	MFS_GLUT_Class1	14..458	CDD:340989	142/474 (30%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	282..288		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337924
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740