DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-1 and Slc2a6

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_766247.2	Gene:	Slc2a6 / 227659	MGIID:	2443286	Length:	497	Species:	Mus musculus

Alignment Length:	462	Identity:	148/462 - (32%)
Similarity:	236/462 - (51%)	Gaps:	20/462 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 LAALSVSLGSLVVGFVSAYTSPALVSMTDRNITSFEVTQDAGSWVGGIMPLAGLAGGIAGGPLIE 462
            ||..:..||:...|:...||||.:..:...:..:..:.:...||.|.:..|...|||::...|.:
Mouse    39 LATFAAVLGNFSFGYALVYTSPVIPELKLSSDPALHLDKIQASWFGSVFTLGAAAGGLSAMLLND 103

  Fly   463 YLGRRNTILATAVPFIVSSLLIACAVNVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTL 527
            .|||:.:|:.:|||..:...::|.|..:.|:|.||.|.||..|:.:..:|||:.|...|:|||.|
Mouse   104 LLGRKLSIMFSAVPSAIGYAIMAGARGLWMLLLGRMLTGFAGGLTAACIPVYVSEIAPPDVRGAL 168

  Fly   528 GLLPTAFGNIGILLCFVAGSFMNWSMLAFLGAALPVPFLILMFLIPETPRWFVGRGLEERARKAL 592
            |..|......|.|..:..|..:.|..||..|....:..::|:..:|.:||:.:.:..:|.|.:||
Mouse   169 GATPQLMAVFGSLSLYALGLLLPWRWLAVAGEGPVLIMILLLSFMPNSPRFLLSKSRDEEALQAL 233

  Fly   593 KWLRGKEADVEPELKGLMRSQADADRQASRNTMLELLKLNNLKPLSISLGLMFFQQFSGINAVIF 657
            .|||. :::|..|.:.:   |.:..||:||.:..|..:....:|:.|::.:.|.||.:||..::.
Mouse   234 TWLRA-DSEVHWEFEQI---QDNVRRQSSRVSWAEAREPRVYRPVLIAVLMRFLQQLTGITPILV 294

  Fly   658 YTVQIFKDAGSTIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSDIAMVLTLFVLGGF-- 720
            |...||.:....:.......|||.|..|:..|..|.:|.||||:|||||...|......||.:
Mouse   295 YLQTIFDNTSVVLPSQQDAAIVGAVRLLSVLIAAVTMDLAGRKVLLYVSASVMFAANLTLGLYVQ 359

  Fly   721 FYCKTYGPD------------VSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSAA 773
            |..:...|:            .::|..:||...:::|:|:::|:|||.||:|.|:||.:.||.|:
Mouse   360 FVPRPLTPNSTVEIVTLGDTAFNYLTLIPLLATMLFIMGYAMGWGPITWLLMSEVLPLRARGVAS 424

  Fly   774 SVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLFFVIIYVPETQGKTLEDIERKMM 838
            .:....:|...||:|..|.....|.|....|:.|.|||.:.|.|....||||:|::||.||  ..
Mouse   425 GLCVLVSWLTAFVLTNYFLLAVNAFGLQVPFFFFSAICLLSLLFTGCCVPETRGRSLEQIE--AF 487

  Fly   839 GRVRRMS 845
            ...||||
Mouse   488 FHTRRMS 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	142/448 (32%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	133/434 (31%)
Slc2a6	NP_766247.2	Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS	38..483	CDD:391944	141/447 (32%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	284..290		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834416
Domainoid	1	1.000	299	1.000	Domainoid score	I1432
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69236
Inparanoid	1	1.050	304	1.000	Inparanoid score	I2627
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		mtm8886
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760