DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-1 and Slc2a1

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_035530.2	Gene:	Slc2a1 / 20525	MGIID:	95755	Length:	492	Species:	Mus musculus

Alignment Length:	483	Identity:	146/483 - (30%)
Similarity:	226/483 - (46%)	Gaps:	78/483 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 VLAALSVSLGSLVVGF----VSA----------------YTSPALVSMTDRNITSFEVTQDAGSW 441
            :||.....||||..|:    ::|                |..| :.|.|...:.|..|
Mouse    13 MLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGEP-IPSTTLTTLWSLSV------- 69

  Fly   442 VGGIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIA---CAVNVAMVLCGRFLAGFC 503
              .|..:.|:.|..:.|..:...||||::|...:...|:::|:.   ...:..|::.|||:.|..
Mouse    70 --AIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVAAVLMGFSKLGKSFEMLILGRFIIGVY 132

  Fly   504 VGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVAG--SFMN----WSML---AFLGA 559
            .|:.:..:|:|:||.....:||.||.|......:|||:..|.|  |.|.    |.:|   .|:.|
Mouse   133 CGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPA 197

  Fly   560 ALPVPFLILMFLIPETPRW-FVGRGLEERARKALKWLRGKEADVEPELKGLMRSQADADRQASRN 623
            .|.   .||:...||:||: .:.|..|.||:..||.||| .|||..:|    :...:..||..|.
Mouse   198 LLQ---CILLPFCPESPRFLLINRNEENRAKSVLKKLRG-TADVTRDL----QEMKEEGRQMMRE 254

  Fly   624 ---TMLELLKLNNLK-PLSISLGLMFFQQFSGINAVIFYTVQIFKDAGSTIDGNLCTIIVGIVNF 684
               |:|||.:....: |:.|::.|...||.||||||.:|:..||:.|| .......||..||||.
Mouse   255 KKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAG-VQQPVYATIGSGIVNT 318

  Fly   685 LATFIGIVLIDRAGRKILLYVS-------DIAMVLTLFVLGGFFYCKTYGPDVSHLGWLPLTCFV 742
            ..|.:.:.:::||||:.|..:.       .:.|.:.|.:|...       |.:|:|..:.:..||
Mouse   319 AFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLERL-------PWMSYLSIVAIFGFV 376

  Fly   743 IYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLF 807
            .:   |.:|.|||||.::.|:.....|.:|.:||...||...|:|...||.:....|.: .|.:|
Mouse   377 AF---FEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPY-VFIIF 437

  Fly   808 GAICFVGLFFVIIY--VPETQGKTLEDI 833
            ..:  :.|||:..|  ||||:|:|.::|
Mouse   438 TVL--LVLFFIFTYFKVPETKGRTFDEI 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	145/481 (30%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	137/466 (29%)
Slc2a1	NP_035530.2	Sugar_tr	19..467	CDD:278511	144/477 (30%)
		MFS	62..450	CDD:119392	126/418 (30%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	282..288		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834355
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2166
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.770