DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tret1-1 and SLC2A6

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_060055.2	Gene:	SLC2A6 / 11182	HGNCID:	11011	Length:	507	Species:	Homo sapiens

Alignment Length:	462	Identity:	149/462 - (32%)
Similarity:	232/462 - (50%)	Gaps:	31/462 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 LAALSVSLGSLVVGFVSAYTSPALVSMTDRNITSFEVTQDAGSWVGGIMPLAGLAGGIAGGPLIE 462
            ||..:..||:...|:...||||.:.::.........:|:...||.|.:..|...|||::...|.:
Human    40 LATFAAVLGNFSFGYALVYTSPVIPALERSLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMILND 104

  Fly   463 YLGRRNTILATAVPFIVSSLLIACAVNVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTL 527
            .|||:.:|:.:|||......|:|.|..:.|:|.||.|.||..|:.:..:|||:.|...|.|||.|
Human   105 LLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYVSEIAPPGVRGAL 169

  Fly   528 GLLPTAFGNIGILLCFVAGSFMNWSMLAFLGAALPVPFLILMFLIPETPRWFVGRGLEERARKAL 592
            |..|......|.|..:..|..:.|..||..|.|..:..::|:..:|.:||:.:.||.:|.|.:||
Human   170 GATPQLMAVFGSLSLYALGLLLPWRWLAVAGEAPVLIMILLLSFMPNSPRFLLSRGRDEEALRAL 234

  Fly   593 KWLRGKEADVEPELKGLMRSQADADRQASRNTMLELLKLNNLKPLSISLGLMFFQQFSGINAVIF 657
            .||||.:.||..|.:.:   |.:..||:||.:..|....:..:|::::|.:...||.:||..::.
Human   235 AWLRGTDVDVHWEFEQI---QDNVRRQSSRVSWAEARAPHVCRPITVALLMRLLQQLTGITPILV 296

  Fly   658 YTVQIFKDAGSTIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSDIAMVLTLFVLGGFFY 722
            |...||......:.......|||.|..|:..|..:.:|.||||:||:||...|......||.:.:
Human   297 YLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLIAALTMDLAGRKVLLFVSAAIMFAANLTLGLYIH 361

  Fly   723 CKTYGP-------------------------DVSHLGWLPLTCFVIYILGFSLGFGPIPWLMMGE 762
               :||                         ...:|..:||...:::|:|:::|:|||.||:|.|
Human   362 ---FGPRPLSPNSTAGLESESWGDLAQPLAAPAGYLTLVPLLATMLFIMGYAVGWGPITWLLMSE 423

  Fly   763 ILPAKIRGSAASVATAFNWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLFFVIIYVPETQG 827
            :||.:.||.|:.:....:|...||:||:|..:....|....|:.|.|||.|.|.|....||||:|
Human   424 VLPLRARGVASGLCVLASWLTAFVLTKSFLPVVSTFGLQVPFFFFAAICLVSLVFTGCCVPETKG 488

  Fly   828 KTLEDIE 834
            ::||.||
Human   489 RSLEQIE 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	147/459 (32%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	138/445 (31%)
SLC2A6	NP_060055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS_GLUT6_Class3	39..493	CDD:340992	146/458 (32%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	286..292		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144254
Domainoid	1	1.000	301	1.000	Domainoid score	I1411
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69236
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2630
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	1	1.000	-	-		FOG0000275
OrthoInspector	1	1.000	-	-		mtm8509
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760