DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tret1-1 and slc2a12

DIOPT Version :9

Sequence 1:	NP_610693.1	Gene:	Tret1-1 / 36248	FlyBaseID:	FBgn0050035	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	XP_031758281.1	Gene:	slc2a12 / 100487147	XenbaseID:	XB-GENE-1012136	Length:	591	Species:	Xenopus tropicalis

Alignment Length:	590	Identity:	145/590 - (24%)
Similarity:	247/590 - (41%)	Gaps:	142/590 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 VRQITEDGKPKLEVYRPTTNP-----------IYIWTQVLAALSVSLGSLVVGFVSAYTSPALVS 423
            ::|.:.||.|:       |||           ..:.:.|:||:|    .|:||:.....|.||:.
Frog    12 LQQTSSDGDPR-------TNPRQTGKREGCGAFILLSSVIAAVS----GLLVGYELGIISGALLQ 65

  Fly   424 MTDRNITSFEVTQDAGSWVGGIMPLAGLAGGIAGGPLIEYLGRRNTILATAVPFIVSSLLIACAV 488
            :.    :..|:|......|...:.:......:.||.||:..|||.||:.|::..:.|:||....|
Frog    66 LQ----SLLELTCQQQEIVVSALLIGAFVASLVGGSLIDLYGRRITIIFTSILLVFSNLLPVVIV 126

  Fly   489 NVAMVLCGRFLAGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILLCFVA----GSFM 549
            :...::.||.:.|..:.:::::..||:.|......||.|..|......:|||..::.    .|..
Frog   127 SYGSLIAGRIVIGVSISLSAIATCVYIAEISPQHKRGMLVSLNELMIVVGILFAYICNYLFASVS 191

  Fly   550 N-WSMLAFLGAALPVPFL--ILMFLIPETPRWFVGRGLEERARKALKWLRGKEADVEPELKGLMR 611
            | |..:  .|..:|:..|  |.|:.:|::||:.:.:|.::.|.|.|:.||. ..::..||..: :
Frog   192 NGWKYM--FGLIIPLAALQAIAMYFLPQSPRFLIMKGYDDAAGKVLQKLRA-TTNISEELTAI-K 252

  Fly   612 SQADADRQ-------ASRNTM-LELLKLNNLKPLSISLGLMFFQQFSGINAVIFYTVQIFKDAG- 667
            |...|:.|       .||:.| :.||         |.|.|.||.|.:|...::||...:.|..|
Frog   253 SSIKAEYQYRFLDLFCSRDNMRVRLL---------IGLTLSFFVQITGQPNILFYASTVLKSVGF 308

  Fly   668 -STIDGNLCTIIVGIVNFLATFIGIVLIDRAGRKILLYVSDIAMVLTLFVLG--------GF-FY 722
             ||...:|.:..:|::..::|...|:.:|:.|.|..|.:....|.::|..:|        .| ..
Frog   309 QSTEAASLASTGIGVIKVVSTIPAIIFVDKIGSKTFLCIGSAVMAVSLVSVGLVSLQLDVNFNNI 373

  Fly   723 CKT-------------YGP-----------------------------------------DVS-- 731
            ||.             |||                                         |.|
Frog   374 CKVHTMQNHSLQDSIIYGPLSLSKPNESLFEETSTLESTKASYLSPLNGTKSWHFTTQEVDSSIG 438

  Fly   732 -----------------HLGWLPLTCFVIYILGFSLGFGPIPWLMMGEILPAKIRGSAASVATAF 779
                             ::.||.|...:.::..||:|.||:.||:..||.||.|:|.|.::.::.
Frog   439 VTPKETKIKSQPDGIPEYMKWLCLASLLAFVAAFSIGLGPMAWLVQSEIFPAGIKGRAFAITSSM 503

  Fly   780 NWFCTFVVTKTFQDLTVAMGAHGAFWLFGAICFVGLFFVIIYVPETQGKTLEDIERKMMGRVRRM 844
            ||....:::.||..||..:|.....:.:..:....|.|||::||.|:|:.||:|..::..|
Frog   504 NWGMNLLISLTFLTLTEIIGLPWMLFGYALMSIASLVFVIMFVPNTKGRPLEEISMELANR---- 564

  Fly   845 SSVAN 849
            |.|.|
Frog   565 SYVCN 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tret1-1	NP_610693.1	SP	382..833	CDD:273317	136/560 (24%)
Tret1-1	NP_610693.1	MFS	401..822	CDD:119392	124/519 (24%)
slc2a12	XP_031758281.1	MFS_GLUT12_Class3	40..557	CDD:340993	133/537 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010