DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9003 and GRR1

DIOPT Version :9

Sequence 1:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_012623.1	Gene:	GRR1 / 853552	SGDID:	S000003850	Length:	1151	Species:	Saccharomyces cerevisiae

Alignment Length:	806	Identity:	148/806 - (18%)
Similarity:	273/806 - (33%)	Gaps:	278/806 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 DRSNNNGNNHN------------PSLQLNGNGGSNTRQHSSGSNSRQHSSSSSNSNSSNISPPPS 136
            |:.|||.|:.|            |.|.||.:|..:            .:::::|:|::|.|..|.
Yeast     2 DQDNNNHNDSNRLHPPDIHPNLGPQLWLNSSGDFD------------DNNNNNNNNNNNNSTRPQ 54

  Fly   137 SSSSSRSNNNNNNHSSNIISGFCSTIWR----------------------SATF--GSATPVINP 177
            ..|.:|....:..::|.:.....:.|:|                      |.||  ...|..:|.
Yeast    55 MPSRTRETATSERNASEVRDATLNNIFRFDSIQRETLLPTNNGQPLNQNFSLTFQPQQQTNALNG 119

  Fly   178 LPAVSINPKIMESSSDSCSLSSSTTPDVGLADQQRN-------MAGSAQDQ----SEDQSQTFLG 231
            :...::|..:|...:......:...|:  |.:::|.       :.|....:    .|.:.:..|.
Yeast   120 IDINTVNTNLMNGVNVQIDQLNRLLPN--LPEEERKQIHEFKLIVGKKIQEFLVVIEKRRKKILN 182

  Fly   232 ATELDDELIKQLPKEVLLRVFSYLDVVSLCR---------------------------------- 262
            ..|||:..:|:|..:...:..|||..:...|
Yeast   183 EIELDNLKLKELRIDNSPQAISYLHKLQRMRLRALETENMEIRNLRLKILTIIEEYKKSLYAYCH 247

  Fly   263 ---------------------------------------------------------CAQVCKYW 270
                                                                     |..|.:..
Yeast   248 SKLRGQQVENPTDNFIIWINSIDTTESSDLKEGLQDLSRYSRQFINNVLSNPSNQNICTSVTRRS 312

  Fly   271 NVLALD--------------------------GSSWQKI-----------------NLF------ 286
            .|.||:                          ...|.:|                 :||
Yeast   313 PVFALNMLPSEILHLILDKLNQKYDIVKFLTVSKLWAEIIVKILYYRPHINKKSQLDLFLRTMKL 377

  Fly   287 ----------------------DFQRDIE----------------------GPVIENISQRCRGF 307
                                  |:..|.|                      ...|..:.:.|: |
Yeast   378 TSEETVFNYRLMIKRLNFSFVGDYMHDTELNYFVGCKNLERLTLVFCKHITSVPISAVLRGCK-F 441

  Fly   308 LKSLSLRGCQSVGDQSVRTLANHCHNIEHLDLSDCKKITDISTQSISRYCSKLTAINLHSCSNIT 372
            |:|:.:.|.:.|.|....|||.:|..::...:...:.:|..|.::...:...|..|.:.:.:|:.
Yeast   442 LQSVDITGIRDVSDDVFDTLATYCPRVQGFYVPQARNVTFDSLRNFIVHSPMLKRIKITANNNMN 506

  Fly   373 DNSLKYLSDGCPNLMEINVSWCHLISENGVEALARGCVKLRKFSSKGCKQINDNAIMCLAKY--- 434
            |..::.|::.||.|:|::::....::::.:..|....|:||:|.......|.||....|:|.
Yeast   507 DELVELLANKCPLLVEVDITLSPNVTDSSLLKLLTRLVQLREFRITHNTNITDNLFQELSKVVDD 571

  Fly   435 CPDLMVLNLHSCETITDSSIRQLAANCHKLQKLCVSKCADLTDLTLLSLSQHNHLLNTLEVSGCR 499
            .|.|.:::|..||.|||.:|..:.....||:.:.:.||:.:||.:|..||:....|.|:....|.
Yeast   572 MPSLRLIDLSGCENITDKTIESIVNLAPKLRNVFLGKCSRITDASLFQLSKLGKNLQTVHFGHCF 636

  Fly   500 NFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCELITDDGIRHLTTG 564
            |.||.|.:||..:|..::.:|...|:.:|:.||..|| ..|.|:::.|..|..:||:|:.::.:.
Yeast   637 NITDNGVRALFHSCTRIQYVDFACCTNLTNRTLYELA-DLPKLKRIGLVKCTQMTDEGLLNMVSL 700

  Fly   565 SCAAEILSVLELDNCPLITDRTL-EHLVSCHNLQRIELF--------DCQLITRTA--------- 611
            ....:.|..:.|..|..:|...: |.|:||..|..:.|.        |..:..|.|
Yeast   701 RGRNDTLERVHLSYCSNLTIYPIYELLMSCPRLSHLSLTAVPSFLRPDITMYCRPAPSDFSENQR 765

  Fly   612 ----------IRKLKNHLPNIKVHAY 627
                      :.||:::|.|:...|:
Yeast   766 QIFCVFSGKGVHKLRHYLVNLTSPAF 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	13/178 (7%)
		leucine-rich repeat	280..307	CDD:275381	9/93 (10%)
		AMN1	<308..453	CDD:187754	38/147 (26%)
		leucine-rich repeat	308..327	CDD:275381	5/18 (28%)
		leucine-rich repeat	334..359	CDD:275381	2/24 (8%)
		leucine-rich repeat	360..385	CDD:275381	6/24 (25%)
		leucine-rich repeat	386..411	CDD:275381	3/24 (13%)
		AMN1	<409..586	CDD:187754	55/179 (31%)
		leucine-rich repeat	412..437	CDD:275381	8/27 (30%)
		leucine-rich repeat	438..463	CDD:275381	8/24 (33%)
		leucine-rich repeat	464..515	CDD:275381	18/50 (36%)
		leucine-rich repeat	516..541	CDD:275381	7/24 (29%)
		leucine-rich repeat	542..561	CDD:275381	6/18 (33%)
		leucine-rich repeat	571..595	CDD:275381	8/24 (33%)
		leucine-rich repeat	596..621	CDD:275381	8/51 (16%)
GRR1	NP_012623.1	F-box-like	320..361	CDD:403981	2/40 (5%)
		AMN1	404..559	CDD:187754	31/155 (20%)
		leucine-rich repeat	416..441	CDD:275381	2/25 (8%)
		leucine-rich repeat	442..467	CDD:275381	9/24 (38%)
		leucine-rich repeat	494..519	CDD:275381	6/24 (25%)
		leucine-rich repeat	520..545	CDD:275381	3/24 (13%)
		leucine-rich repeat	546..574	CDD:275381	8/27 (30%)
		AMN1	<574..737	CDD:187754	50/163 (31%)
		leucine-rich repeat	575..600	CDD:275381	8/24 (33%)
		leucine-rich repeat	601..626	CDD:275381	8/24 (33%)
		leucine-rich repeat	627..652	CDD:275381	10/24 (42%)
		leucine-rich repeat	653..677	CDD:275381	7/24 (29%)
		leucine-rich repeat	678..704	CDD:275381	6/25 (24%)
		leucine-rich repeat	707..732	CDD:275381	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68784
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.802101	Normalized mean entropy	S1900
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46756
orthoMCL	1	0.900	-	-		OOG6_101086
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720