DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9003 and RAD7

DIOPT Version :9

Sequence 1:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_012586.1	Gene:	RAD7 / 853512	SGDID:	S000003813	Length:	565	Species:	Saccharomyces cerevisiae

Alignment Length:	491	Identity:	112/491 - (22%)
Similarity:	208/491 - (42%)	Gaps:	73/491 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 GSATPVINPLPAVSINPKIMESSSDS------------CSLSSSTTPDVGLADQQRNMAGSAQDQ 221
            ||.|.......:.....|::.:.||.            .||||:...: .|..:::|.|...|::
Yeast    84 GSGTETERAQVSYDARMKLVPADSDEEEYETSHISDTPVSLSSANDRE-SLTKKRQNTAKIIQNR 147

  Fly   222 SEDQSQTFLGATELDDELIKQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGSSWQKIN-- 284
            ...:.:    |.:|.|.           ||.....:.|||    :.|    ::.:.|.|||..
Yeast   148 RRKRKR----AADLLDR-----------RVNKVSSLQSLC----ITK----ISENISKWQKEADE 189

  Fly   285 ----LFDFQRDIEGPV-IENISQRCRGFLKSLSLRGCQSVGDQSVRTLANHCHNIEHLDLSDCKK 344
                :|:..||:.|.| ..|::...:...|:      :::.|.:::....  .:::.|..|||.|
Yeast   190 SSKLVFNKLRDVLGGVSTANLNNLAKALSKN------RALNDHTLQLFLK--TDLKRLTFSDCSK 246

  Fly   345 ITDISTQSISRYCSKLTAINLHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENGVE---ALA 406
            |:....::::.:...||.::|..|..:...||.|:::..|||..:|:....||:|:..|   .:.
Yeast   247 ISFDGYKTLAIFSPHLTELSLQMCGQLNHESLLYIAEKLPNLKSLNLDGPFLINEDTWEKFFVIM 311

  Fly   407 RGCVKLRKFSSKGCKQINDNAIMCLAKYCPDLMV-LNLHSCETITD-SSIRQLAANCHKLQKLCV 469
            :|  :|.:|......:..|.::..|...|...:| |.|...::|:: :.:.|...| .:...||:
Yeast   312 KG--RLEEFHISNTHRFTDKSLSNLLINCGSTLVSLGLSRLDSISNYALLPQYLVN-DEFHSLCI 373

  Fly   470 S---KCADLTDLTLLS-LSQHNHLLNTLEVSGCRNFTDI----GFQA-LGRNCKYLERMDLEECS 525
            .   ...|:.|..::: |.|....|..|.::||.:.||.    |..| :...|. ||.:.|||..
Yeast   374 EYPFNEEDVNDEIIINLLGQIGRTLRKLVLNGCIDLTDSMIINGLTAFIPEKCP-LEVLSLEESD 437

  Fly   526 QITDLTLAHLATGCP--SLEKLTLSHCELITDDGIRHLTTGSCAAEILSVLELDNCPLITDRTLE 588
            |||..:|::..:...  :|.:.:...|..:.|..|..|.... |.:.|..|.|::...:|.....
Yeast   438 QITTDSLSYFFSKVELNNLIECSFRRCLQLGDMAIIELLLNG-ARDSLRSLNLNSLKELTKEAFV 501

  Fly   589 HLVSCHNLQRIELFDCQLITRTAIRKLKNHLPNIKV 624
            .| :|.||..::|...:.:..:.|:.|....||:.|
Yeast   502 AL-ACPNLTYLDLGFVRCVDDSVIQMLGEQNPNLTV 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	10/50 (20%)
		leucine-rich repeat	280..307	CDD:275381	9/33 (27%)
		AMN1	<308..453	CDD:187754	33/149 (22%)
		leucine-rich repeat	308..327	CDD:275381	2/18 (11%)
		leucine-rich repeat	334..359	CDD:275381	6/24 (25%)
		leucine-rich repeat	360..385	CDD:275381	7/24 (29%)
		leucine-rich repeat	386..411	CDD:275381	7/27 (26%)
		AMN1	<409..586	CDD:187754	45/189 (24%)
		leucine-rich repeat	412..437	CDD:275381	5/24 (21%)
		leucine-rich repeat	438..463	CDD:275381	6/26 (23%)
		leucine-rich repeat	464..515	CDD:275381	15/59 (25%)
		leucine-rich repeat	516..541	CDD:275381	9/26 (35%)
		leucine-rich repeat	542..561	CDD:275381	4/18 (22%)
		leucine-rich repeat	571..595	CDD:275381	6/23 (26%)
		leucine-rich repeat	596..621	CDD:275381	4/24 (17%)
RAD7	NP_012586.1	AMN1	228..440	CDD:187754	54/217 (25%)
		leucine-rich repeat	236..261	CDD:275381	6/24 (25%)
		leucine-rich repeat	262..287	CDD:275381	7/24 (29%)
		leucine-rich repeat	288..340	CDD:275381	12/53 (23%)
		leucine-rich repeat	342..365	CDD:275381	5/22 (23%)
		leucine-rich repeat	368..397	CDD:275381	6/28 (21%)
		leucine-rich repeat	398..426	CDD:275381	8/27 (30%)
		leucine-rich repeat	428..455	CDD:275381	9/26 (35%)
		leucine-rich repeat	456..475	CDD:275381	4/18 (22%)
		leucine-rich repeat	484..507	CDD:275381	6/23 (26%)
		leucine-rich repeat	508..533	CDD:275381	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I1756
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.990