DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9003 and FBXL20

DIOPT Version :9

Sequence 1:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001357137.1	Gene:	FBXL20 / 84961	HGNCID:	24679	Length:	473	Species:	Homo sapiens

Alignment Length:	417	Identity:	245/417 - (58%)
Similarity:	314/417 - (75%)	Gaps:	2/417 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 DELI--KQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGSSWQKINLFDFQRDIEGPVIEN 299
            ||.:  |:||||:|||:||:||||:|||||||.:.|||||||||:||:|:||||||||||.|:||
Human    57 DEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVEN 121

  Fly   300 ISQRCRGFLKSLSLRGCQSVGDQSVRTLANHCHNIEHLDLSDCKKITDISTQSISRYCSKLTAIN 364
            ||:||.|||:.||||||..|||.::||.|.:|.|||.|:|:.|.|.||.:..|:|::||||..::
Human   122 ISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDATCTSLSKFCSKLRHLD 186

  Fly   365 LHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENGVEALARGCVKLRKFSSKGCKQINDNAIM 429
            |.||::||:.|||.||:|||.|.::|:|||..::::|::||.|||..|:....|||.|:.|.|:.
Human   187 LASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALK 251

  Fly   430 CLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKLQKLCVSKCADLTDLTLLSLSQHNHLLNTLE 494
            .:..:||:|:.|||.:|..|||..:..:...|||||.||.|.|:::||..|.:|.|:...|..||
Human   252 YIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILE 316

  Fly   495 VSGCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCELITDDGIR 559
            |:.|...||:||..|.|||..||:||||||.||||.||..|:..||.|:.|:|||||||||||||
Human   317 VARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIR 381

  Fly   560 HLTTGSCAAEILSVLELDNCPLITDRTLEHLVSCHNLQRIELFDCQLITRTAIRKLKNHLPNIKV 624
            ||..|:||.:.|.|:||||||||||.:||||.|||:|:||||:|||.|||..|::|:.|||||||
Human   382 HLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKV 446

  Fly   625 HAYFAPGTPPAVTSGHRPRYCRCCEIL 651
            ||||||.|||....|.|.|:||||.||
Human   447 HAYFAPVTPPPSVGGSRQRFCRCCIIL 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	33/46 (72%)
		leucine-rich repeat	280..307	CDD:275381	20/26 (77%)
		AMN1	<308..453	CDD:187754	70/144 (49%)
		leucine-rich repeat	308..327	CDD:275381	11/18 (61%)
		leucine-rich repeat	334..359	CDD:275381	11/24 (46%)
		leucine-rich repeat	360..385	CDD:275381	13/24 (54%)
		leucine-rich repeat	386..411	CDD:275381	11/24 (46%)
		AMN1	<409..586	CDD:187754	94/176 (53%)
		leucine-rich repeat	412..437	CDD:275381	8/24 (33%)
		leucine-rich repeat	438..463	CDD:275381	9/24 (38%)
		leucine-rich repeat	464..515	CDD:275381	24/50 (48%)
		leucine-rich repeat	516..541	CDD:275381	16/24 (67%)
		leucine-rich repeat	542..561	CDD:275381	15/18 (83%)
		leucine-rich repeat	571..595	CDD:275381	18/23 (78%)
		leucine-rich repeat	596..621	CDD:275381	15/24 (63%)
FBXL20	NP_001357137.1	F-box-like	64..106	CDD:338561	31/41 (76%)
		leucine-rich repeat	102..129	CDD:275381	20/26 (77%)
		AMN1	130..326	CDD:355707	90/195 (46%)
		leucine-rich repeat	130..149	CDD:275381	11/18 (61%)
		leucine-rich repeat	156..181	CDD:275381	11/24 (46%)
		leucine-rich repeat	182..207	CDD:275381	13/24 (54%)
		leucine-rich repeat	208..233	CDD:275381	11/24 (46%)
		leucine-rich repeat	234..259	CDD:275381	8/24 (33%)
		AMN1	257..431	CDD:355707	102/173 (59%)
		leucine-rich repeat	260..285	CDD:275381	9/24 (38%)
		leucine-rich repeat	286..311	CDD:275381	11/24 (46%)
		leucine-rich repeat	312..337	CDD:275381	13/24 (54%)
		leucine-rich repeat	338..363	CDD:275381	16/24 (67%)
		leucine-rich repeat	364..392	CDD:275381	20/27 (74%)
		leucine-rich repeat	393..417	CDD:275381	18/23 (78%)
		leucine-rich repeat	418..443	CDD:275381	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153019
Domainoid	1	1.000	135	1.000	Domainoid score	I4981
eggNOG	1	0.900	-	-		E1_KOG4341
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68784
Inparanoid	1	1.050	520	1.000	Inparanoid score	I1275
Isobase	1	0.950	-	0.802101	Normalized mean entropy	S1900
OMA	1	1.010	-	-		QHG52856
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	1	1.000	-	-		FOG0002896
OrthoInspector	1	1.000	-	-		otm42042
orthoMCL	1	0.900	-	-		OOG6_101086
Panther	1	1.100	-	-	LDO	PTHR13318
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	1	1.000	-	-		X1911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.790