DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9003 and Fbxl20

DIOPT Version :9

Sequence 1:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	XP_006534361.1	Gene:	Fbxl20 / 72194	MGIID:	1919444	Length:	438	Species:	Mus musculus

Alignment Length:	417	Identity:	245/417 - (58%)
Similarity:	313/417 - (75%)	Gaps:	2/417 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 DELI--KQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGSSWQKINLFDFQRDIEGPVIEN 299
            ||.:  |:||||:|||:||:||||:|||||||.:.|||||||||:||:|:||||||||||.|:||
Mouse    22 DEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVEN 86

  Fly   300 ISQRCRGFLKSLSLRGCQSVGDQSVRTLANHCHNIEHLDLSDCKKITDISTQSISRYCSKLTAIN 364
            ||:||.|||:.||||||..|||.::||.|.:|.|||.|.|:.|.|.||.:..|:|::||||..::
Mouse    87 ISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLSLNGCTKTTDATCTSLSKFCSKLRHLD 151

  Fly   365 LHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENGVEALARGCVKLRKFSSKGCKQINDNAIM 429
            |.||::||:.|||.||:|||.|.::|:|||..::::|::||.|||..|:....|||.|:.|.|:.
Mouse   152 LASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALK 216

  Fly   430 CLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKLQKLCVSKCADLTDLTLLSLSQHNHLLNTLE 494
            .:..:||:|:.|||.:|..|||..:..:...|||||.||.|.|:::||..|.:|.|:...|..||
Mouse   217 YIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILE 281

  Fly   495 VSGCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCELITDDGIR 559
            |:.|...||:||..|.|||..||:||||||.||||.||..|:..||.|:.|:|||||||||||||
Mouse   282 VARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIR 346

  Fly   560 HLTTGSCAAEILSVLELDNCPLITDRTLEHLVSCHNLQRIELFDCQLITRTAIRKLKNHLPNIKV 624
            ||..|:||.:.|.|:||||||||||.:||||.|||:|:||||:|||.|||..|::|:.|||||||
Mouse   347 HLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKV 411

  Fly   625 HAYFAPGTPPAVTSGHRPRYCRCCEIL 651
            ||||||.|||....|.|.|:||||.||
Mouse   412 HAYFAPVTPPPSVGGSRQRFCRCCIIL 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	33/46 (72%)
		leucine-rich repeat	280..307	CDD:275381	20/26 (77%)
		AMN1	<308..453	CDD:187754	70/144 (49%)
		leucine-rich repeat	308..327	CDD:275381	11/18 (61%)
		leucine-rich repeat	334..359	CDD:275381	11/24 (46%)
		leucine-rich repeat	360..385	CDD:275381	13/24 (54%)
		leucine-rich repeat	386..411	CDD:275381	11/24 (46%)
		AMN1	<409..586	CDD:187754	94/176 (53%)
		leucine-rich repeat	412..437	CDD:275381	8/24 (33%)
		leucine-rich repeat	438..463	CDD:275381	9/24 (38%)
		leucine-rich repeat	464..515	CDD:275381	24/50 (48%)
		leucine-rich repeat	516..541	CDD:275381	16/24 (67%)
		leucine-rich repeat	542..561	CDD:275381	15/18 (83%)
		leucine-rich repeat	571..595	CDD:275381	18/23 (78%)
		leucine-rich repeat	596..621	CDD:275381	15/24 (63%)
Fbxl20	XP_006534361.1	F-box-like	30..71	CDD:403981	31/40 (78%)
		leucine-rich repeat	67..94	CDD:275381	20/26 (77%)
		AMN1	95..291	CDD:187754	90/195 (46%)
		leucine-rich repeat	95..114	CDD:275381	11/18 (61%)
		leucine-rich repeat	121..146	CDD:275381	11/24 (46%)
		leucine-rich repeat	147..172	CDD:275381	13/24 (54%)
		leucine-rich repeat	173..198	CDD:275381	11/24 (46%)
		leucine-rich repeat	199..224	CDD:275381	8/24 (33%)
		AMN1	222..396	CDD:187754	102/173 (59%)
		leucine-rich repeat	225..250	CDD:275381	9/24 (38%)
		leucine-rich repeat	251..276	CDD:275381	11/24 (46%)
		leucine-rich repeat	277..302	CDD:275381	13/24 (54%)
		leucine-rich repeat	303..328	CDD:275381	16/24 (67%)
		leucine-rich repeat	329..357	CDD:275381	20/27 (74%)
		leucine-rich repeat	358..382	CDD:275381	18/23 (78%)
		leucine-rich repeat	383..408	CDD:275381	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843111
Domainoid	1	1.000	135	1.000	Domainoid score	I4956
eggNOG	1	0.900	-	-		E1_KOG4341
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68784
Inparanoid	1	1.050	520	1.000	Inparanoid score	I1258
Isobase	1	0.950	-	0.802101	Normalized mean entropy	S1900
OMA	1	1.010	-	-		QHG52856
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	1	1.000	-	-		FOG0002896
OrthoInspector	1	1.000	-	-		otm44095
orthoMCL	1	0.900	-	-		OOG6_101086
Panther	1	1.100	-	-	LDO	PTHR13318
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	1	1.000	-	-		X1911
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790