Protein Alignment CG9003 and SKP2

DIOPT Version :10

• Sequence 1: NP_001097271.1
• Gene: CG9003 / 36244
• FlyBaseID: FBgn0033639
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_005974.2
• Gene: SKP2 / 6502
• HGNCID: 10901
• Length: 424
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 94/343 - (27%)
• Similarity: 149/343 - (43%)
• Gaps: 80/343 - (23%)

  Fly   243 LPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGSSWQKINLF--DFQRDIEGPVIEN--ISQR 303
            ||.|:||.:||.|.:..|.:.:.|||.|..||.|.|.||.::|.  :...|:.|.::..  |:.|
Human   100 LPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFR 164

  Fly   304 C-RGFLKSLSLRGCQSVGDQSVRTLANHC--HNIEHLDLSDCKKITDIST-QSISRYCSK----- 359
            | |.|:            ||   .||.|.  ..::|:|||:  .:.::|| ..|...|||
Human   165 CPRSFM------------DQ---PLAEHFSPFRVQHMDLSN--SVIEVSTLHGILSQCSKLQNLS 212

  Fly   360 -------------------LTAINLHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENGVE-A 404
                               |..:||..||..::.:|:.|...|..|.|:|:|||...:|..|: |
Human   213 LEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVA 277

  Fly   405 LARGCVKLRKFSSKGC-KQINDNAIMCLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKLQKLC 468
            :|.....:.:.:..|. |.:..:.:..|.:.||:|:.|:|.....:.:...::. ...:.||.|.
Human   278 VAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEF-FQLNYLQHLS 341

  Fly   469 VSKCADLTDLTLLSLSQHNHLLNTLEVSG--------------------CRNFTDIGFQALGRNC 513
            :|:|.|:...|||.|.: ...|.||:|.|                    |.:||.|....:| |.
Human   342 LSRCYDIIPETLLELGE-IPTLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIG-NK 404

  Fly   514 KYLE------RMDLEECS 525
            |..|      |:.|::.|
Human   405 KNQEIWGIKCRLTLQKPS 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box_FBXL2-like	237..281	CDD:438887	17/37 (46%)
		leucine-rich repeat	280..307	CDD:275381	9/31 (29%)
		AMN1	<308..453	CDD:187754	41/173 (24%)
		leucine-rich repeat	308..327	CDD:275381	2/18 (11%)
		leucine-rich repeat	334..359	CDD:275381	8/25 (32%)
		leucine-rich repeat	360..385	CDD:275381	8/24 (33%)
		leucine-rich repeat	386..411	CDD:275381	10/25 (40%)
		AMN1	<409..586	CDD:187754	34/144 (24%)
		leucine-rich repeat	412..437	CDD:275381	4/25 (16%)
		leucine-rich repeat	438..463	CDD:275381	3/24 (13%)
		leucine-rich repeat	464..515	CDD:275381	21/70 (30%)
		leucine-rich repeat	516..541	CDD:275381	4/16 (25%)
		leucine-rich repeat	542..561	CDD:275381
		leucine-rich repeat	571..595	CDD:275381
		leucine-rich repeat	596..621	CDD:275381
SKP2	NP_005974.2	Mediates interaction with hepatitis C virus non-structural protein NS5A. /evidence=ECO:0000269|PubMed:27194766	1..220		42/136 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..73
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22770219	67..73
		F-box_FBXL1	97..137	CDD:438886	17/36 (47%)
		leucine-rich repeat	183..207	CDD:275381	8/25 (32%)
		AMN1	193..>345	CDD:187754	36/152 (24%)
		leucine-rich repeat	208..231	CDD:275381	0/22 (0%)
		LRR 3. /evidence=ECO:0000269|PubMed:11099048	210..234		1/23 (4%)
		leucine-rich repeat	232..257	CDD:275381	8/24 (33%)
		LRR 4. /evidence=ECO:0000269|PubMed:11099048	235..257		7/21 (33%)
		leucine-rich repeat	258..284	CDD:275381	10/25 (40%)
		LRR 5. /evidence=ECO:0000269|PubMed:11099048	258..284		10/25 (40%)
		leucine-rich repeat	285..311	CDD:275381	4/25 (16%)
		LRR 6. /evidence=ECO:0000269|PubMed:11099048	286..308		3/21 (14%)
		LRR 7. /evidence=ECO:0000269|PubMed:11099048	309..330		5/20 (25%)
		leucine-rich repeat	312..336	CDD:275381	3/24 (13%)
		LRR 8. /evidence=ECO:0000269|PubMed:11099048	334..356		9/21 (43%)
		leucine-rich repeat	337..356	CDD:275381	9/18 (50%)
		LRR 9. /evidence=ECO:0000269|PubMed:11099048	359..378		5/18 (28%)
		leucine-rich repeat	365..392	CDD:275381	4/26 (15%)
		LRR 10. /evidence=ECO:0000269|PubMed:11099048	380..401		4/20 (20%)
		Mediates interaction with IFI27. /evidence=ECO:0000269|PubMed:27194766	402..424		7/22 (32%)