DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9003 and FBXL17

DIOPT Version :9

Sequence 1:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	XP_005272105.1	Gene:	FBXL17 / 64839	HGNCID:	13615	Length:	712	Species:	Homo sapiens

Alignment Length:	584	Identity:	125/584 - (21%)
Similarity:	208/584 - (35%)	Gaps:	189/584 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GSSSSNNGGGSSSNSGGAGGSI------------------ELLCPPSGSSSISGSASFSSNSGAS 68
            |......|||.....|.|||..                  :.||||..|.:..|:.     :.|.
Human   216 GGGGCGGGGGGGGGGGPAGGGASPPRPPDAGCCQAPEQPPQPLCPPPSSPTSEGAP-----TEAG 275

  Fly    69 GSSSQTHSTAVSSATDRSNNNGNNHNPSLQLNGNGGSNTRQHSSG-SNSRQHSSSSSNSNSSNIS 132
            |.:.:...||..||                        .:||..| ::.|:   |..|....:..
Human   276 GDAVRAGGTAPLSA------------------------QQQHECGDADCRE---SPENPCDCHRE 313

  Fly   133 PPPSSSSSSRSNNNNNNHSSNIISGFCSTIWRSATFGSATPVINPLPAVSINPKIMESSSDSCSL 197
            |||.
Human   314 PPPE------------------------------------------------------------- 317

  Fly   198 SSSTTPDVGLADQQRNMAGSAQDQSEDQSQTFLGATELDDELIKQLPKEVLLRVFSYLDVVSLCR 262
                |||                                   |.|||..:||::||.|.:...|.
Human   318 ----TPD-----------------------------------INQLPPSILLKIFSNLSLDERCL 343

  Fly   263 CAQ-VCKYWNVLALDGSSWQKINLFDFQRDIEGPVIENISQRCRGFLKSLSLRGCQSVGDQSVRT 326
            .|. |||||..|.||...|::::|...|: :...::|.|:.|.:..:: :::..|:|:.|..|..
Human   344 SASLVCKYWRDLCLDFQFWKQLDLSSRQQ-VTDELLEKIASRSQNIIE-INISDCRSMSDNGVCV 406

  Fly   327 LANHCHNIEHLDLSDCKKITDISTQSISRYCSKLTAINLHSCSNITDNSLKYLSDGCPNLMEINV 391
            ||..|..:.......||:::|.|..:::.:|..|..:::.:...:||..||.|...|..|.:|:.
Human   407 LAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHF 471

  Fly   392 SWCHLISENGVEALARGCVKLRKFSSKGCKQINDNAIMCLAKYCPDLMVLNLHSCETITDSSIRQ 456
            ..|:.||:.|:..:|:||:||::...:..|.:.|.::...|::||:|..:....| ::|...:..
Human   472 GQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGC-SVTSKGVIH 535

  Fly   457 LAANCHKLQKL------------------CVSKCADLTDLTLL-----------SLSQHNHLLNT 492
            |.    ||:.|                  .|.:|.:|:.|.|.           .:::....|..
Human   536 LT----KLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKE 596

  Fly   493 LEVSGCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCELITDD 556
            |.:..|: .||....|:||....:|.:|:..|.:|||.....:|....||..|.|..|:.:..|
Human   597 LYLVSCK-ITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVRVD 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	20/45 (44%)
		leucine-rich repeat	280..307	CDD:275381	6/26 (23%)
		AMN1	<308..453	CDD:187754	38/144 (26%)
		leucine-rich repeat	308..327	CDD:275381	4/18 (22%)
		leucine-rich repeat	334..359	CDD:275381	5/24 (21%)
		leucine-rich repeat	360..385	CDD:275381	7/24 (29%)
		leucine-rich repeat	386..411	CDD:275381	9/24 (38%)
		AMN1	<409..586	CDD:187754	41/177 (23%)
		leucine-rich repeat	412..437	CDD:275381	5/24 (21%)
		leucine-rich repeat	438..463	CDD:275381	4/24 (17%)
		leucine-rich repeat	464..515	CDD:275381	15/79 (19%)
		leucine-rich repeat	516..541	CDD:275381	7/24 (29%)
		leucine-rich repeat	542..561	CDD:275381	5/15 (33%)
		leucine-rich repeat	571..595	CDD:275381
		leucine-rich repeat	596..621	CDD:275381
FBXL17	XP_005272105.1	F-box-like	321..368	CDD:289689	20/46 (43%)
		leucine-rich repeat	362..387	CDD:275381	6/25 (24%)
		leucine-rich repeat	388..413	CDD:275381	7/25 (28%)
		AMN1	411..573	CDD:187754	40/166 (24%)
		leucine-rich repeat	414..439	CDD:275381	5/24 (21%)
		leucine-rich repeat	440..465	CDD:275381	7/24 (29%)
		leucine-rich repeat	466..491	CDD:275381	9/24 (38%)
		leucine-rich repeat	492..517	CDD:275381	5/24 (21%)
		leucine-rich repeat	518..541	CDD:275381	6/27 (22%)
		leucine-rich repeat	542..567	CDD:275381	3/24 (13%)
		AMN1	547..>652	CDD:187754	24/105 (23%)
		leucine-rich repeat	568..593	CDD:275381	3/24 (13%)
		leucine-rich repeat	594..615	CDD:275381	7/21 (33%)
		leucine-rich repeat	619..641	CDD:275381	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153016
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.800