Protein Alignment CG9003 and FBXL19

DIOPT Version :10

• Sequence 1: NP_001097271.1
• Gene: CG9003 / 36244
• FlyBaseID: FBgn0033639
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: NP_001093254.2
• Gene: FBXL19 / 54620
• HGNCID: 25300
• Length: 694
• Species: Homo sapiens
• Alignment Length: 469
• Identity: 111/469 - (23%)
• Similarity: 162/469 - (34%)
• Gaps: 134/469 - (28%)

  Fly   111 SSGSNSRQHSSSSSNSNSSNISP-------PPSSSSSSRSNNNNNNHSSNIISGFCSTIWRSATF 168
            ||.|:|...|.||..|.|.:.:|       .|:..||....|.....:....||.....|   ..
Human   325 SSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSW---PL 386

  Fly   169 GSATP---------VINPLPAVSINPKIMESSSDSCSLSSSTTPD-VGLADQQRNMAGSAQDQSE 223
            |.|.|         |:.|.|                   .|..|| :.||      |||..
Human   387 GPAPPPRPPQLERHVVRPPP-------------------RSPEPDTLPLA------AGSDH---- 422

  Fly   224 DQSQTFLGATELDDELIKQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGSSWQKINLFDF 288
                              .||:...||||.:|....||.|.:||:.|:....|...|.:::| ..
Human   423 ------------------PLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDL-SR 468

  Fly   289 QRDIEGPVIENISQRCRGFLKSLSLRGCQSVGDQSVRTLANHCHNIEHLDLSDCKKITDISTQSI 353
            ::.:..|::..:.:|....| .||..|   |..:.:..|.|....::.|.||.|      |..|:
Human   469 RKSLTPPMLSGVVRRQPRAL-DLSWTG---VSKKQLMWLLNRLQGLQELVLSGC------SWLSV 523

  Fly   354 SRYCS----KLTAINLHSCSNITDNSLKYL----SDGCPNLMEINVSWCHLISENGVEALARGCV 410
            |...|    .|..::|....::.|:.|:.|    .|..|...|             .....:|..
Human   524 SALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTE-------------SRGRLQGVA 575

  Fly   411 KLRKFSSKGCKQINDNAIMCLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKLQKLCVSKCADL 475
            :||...    .::.|.::..|.::.|.|..|:|..|..:.|.|:..|.|....|::..|.
Human   576 ELRLAG----LELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVH----- 631

  Fly   476 TDLTLLSLSQHNHLLNTLEVSGCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATG-- 538
                             |.::||...|| ....|.|.|..|.|:||..|.|::....|.||..
Human   632 -----------------LNLAGCHRLTD-HCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGP 678

  Fly   539 -----CPSLEKLTL 547
                 ||. |||.|
Human   679 PGPFRCPE-EKLLL 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box_FBXL2-like	237..281	CDD:438887	14/43 (33%)
		leucine-rich repeat	280..307	CDD:275381	4/26 (15%)
		AMN1	<308..453	CDD:187754	34/152 (22%)
		leucine-rich repeat	308..327	CDD:275381	5/18 (28%)
		leucine-rich repeat	334..359	CDD:275381	8/28 (29%)
		leucine-rich repeat	360..385	CDD:275381	6/28 (21%)
		leucine-rich repeat	386..411	CDD:275381	2/24 (8%)
		AMN1	<409..586	CDD:187754	38/146 (26%)
		leucine-rich repeat	412..437	CDD:275381	4/24 (17%)
		leucine-rich repeat	438..463	CDD:275381	8/24 (33%)
		leucine-rich repeat	464..515	CDD:275381	10/50 (20%)
		leucine-rich repeat	516..541	CDD:275381	10/31 (32%)
		leucine-rich repeat	542..561	CDD:275381	4/6 (67%)
		leucine-rich repeat	571..595	CDD:275381
		leucine-rich repeat	596..621	CDD:275381
FBXL19	NP_001093254.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		zf-CXXC	<50..77	CDD:366873
		PHD_FXL19	87..148	CDD:277115
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	150..420		29/122 (24%)
		F-box_JHDM	421..463	CDD:438894	15/63 (24%)
		leucine-rich repeat	461..485	CDD:275381	4/24 (17%)
		AMN1	466..665	CDD:187754	55/249 (22%)
		leucine-rich repeat	486..508	CDD:275381	7/25 (28%)
		LRR 1	492..517		6/27 (22%)
		leucine-rich repeat	510..533	CDD:275381	8/28 (29%)
		LRR 2	518..541		7/28 (25%)
		leucine-rich repeat	534..573	CDD:275381	8/51 (16%)
		leucine-rich repeat	574..598	CDD:275381	4/27 (15%)
		LRR 3	581..606		6/28 (21%)
		leucine-rich repeat	599..623	CDD:275381	8/23 (35%)
		LRR 4	607..636		8/50 (16%)
		leucine-rich repeat	629..653	CDD:275381	9/46 (20%)
		LRR 5	637..661		10/24 (42%)
		leucine-rich repeat	654..686	CDD:275381	10/31 (32%)
		LRR 6	662..694		11/31 (35%)