DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9003 and fbxl2

DIOPT Version :9

Sequence 1:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_956400.1	Gene:	fbxl2 / 378737	ZFINID:	ZDB-GENE-030925-12	Length:	432	Species:	Danio rerio

Alignment Length:	418	Identity:	238/418 - (56%)
Similarity:	308/418 - (73%)	Gaps:	2/418 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 DDE--LIKQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGSSWQKINLFDFQRDIEGPVIE 298
            :||  :.|:||||:|||:|||||||:|||||||.|.|||||||||:||||:||:||.||||.|:|
Zfish    15 NDEAPINKKLPKELLLRIFSYLDVVTLCRCAQVSKAWNVLALDGSNWQKIDLFNFQTDIEGRVVE 79

  Fly   299 NISQRCRGFLKSLSLRGCQSVGDQSVRTLANHCHNIEHLDLSDCKKITDISTQSISRYCSKLTAI 363
            |||:||.|||:.||||||.||||.|::|.|.:|.|||||:|:.|.||||.:..|:|::|.||..:
Zfish    80 NISKRCGGFLRQLSLRGCLSVGDASMKTFAQNCRNIEHLNLNGCTKITDSTCISLSKFCFKLRHL 144

  Fly   364 NLHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENGVEALARGCVKLRKFSSKGCKQINDNAI 428
            :|.||.:||:::||.||:||..|..:|:|||..|:.:|:|||:|||..||....:||.|::|.|:
Zfish   145 DLTSCVSITNHALKALSEGCRMLENLNLSWCDQITSDGIEALSRGCTALRALFLRGCTQLDDTAL 209

  Fly   429 MCLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKLQKLCVSKCADLTDLTLLSLSQHNHLLNTL 493
            ..|.|:||:||.:|:.||..|||.....|...|||||.:|:|.|:::||.:|.:|..:...|..|
Zfish   210 KHLQKHCPELMTINMQSCTQITDDGFVSLCRGCHKLQMVCISGCSNITDASLTALGLNCQRLKIL 274

  Fly   494 EVSGCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCELITDDGI 558
            |.:.|.:.||.||..|.|||..:|:||||||..:||.||..|:..||.|:.|:||||||||||||
Zfish   275 EAARCSHVTDAGFTVLARNCHEMEKMDLEECILVTDNTLVQLSIHCPRLQALSLSHCELITDDGI 339

  Fly   559 RHLTTGSCAAEILSVLELDNCPLITDRTLEHLVSCHNLQRIELFDCQLITRTAIRKLKNHLPNIK 623
            |||::..|..|.|.|:||||||||||.|||||.:|..|:||||:|||.::|..|::::.|||.||
Zfish   340 RHLSSSVCGQERLQVVELDNCPLITDITLEHLKNCQRLERIELYDCQQVSRAGIKRIRAHLPEIK 404

  Fly   624 VHAYFAPGTPPAVTSGHRPRYCRCCEIL 651
            |||||||.|||....|...|.||||.||
Zfish   405 VHAYFAPVTPPPSVHGGGQRLCRCCVIL 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	36/44 (82%)
		leucine-rich repeat	280..307	CDD:275381	19/26 (73%)
		AMN1	<308..453	CDD:187754	74/144 (51%)
		leucine-rich repeat	308..327	CDD:275381	12/18 (67%)
		leucine-rich repeat	334..359	CDD:275381	13/24 (54%)
		leucine-rich repeat	360..385	CDD:275381	12/24 (50%)
		leucine-rich repeat	386..411	CDD:275381	13/24 (54%)
		AMN1	<409..586	CDD:187754	90/176 (51%)
		leucine-rich repeat	412..437	CDD:275381	10/24 (42%)
		leucine-rich repeat	438..463	CDD:275381	10/24 (42%)
		leucine-rich repeat	464..515	CDD:275381	21/50 (42%)
		leucine-rich repeat	516..541	CDD:275381	13/24 (54%)
		leucine-rich repeat	542..561	CDD:275381	15/18 (83%)
		leucine-rich repeat	571..595	CDD:275381	18/23 (78%)
		leucine-rich repeat	596..621	CDD:275381	12/24 (50%)
fbxl2	NP_956400.1	F-box-like	24..66	CDD:289689	35/41 (85%)
		leucine-rich repeat	61..88	CDD:275381	19/26 (73%)
		AMN1	63..284	CDD:187754	110/220 (50%)
		leucine-rich repeat	89..108	CDD:275381	12/18 (67%)
		leucine-rich repeat	115..140	CDD:275381	13/24 (54%)
		leucine-rich repeat	141..166	CDD:275381	12/24 (50%)
		leucine-rich repeat	167..192	CDD:275381	13/24 (54%)
		leucine-rich repeat	193..218	CDD:275381	10/24 (42%)
		AMN1	212..390	CDD:187754	96/177 (54%)
		leucine-rich repeat	219..244	CDD:275381	10/24 (42%)
		leucine-rich repeat	245..270	CDD:275381	9/24 (38%)
		leucine-rich repeat	271..296	CDD:275381	12/24 (50%)
		leucine-rich repeat	297..322	CDD:275381	13/24 (54%)
		leucine-rich repeat	323..351	CDD:275381	18/27 (67%)
		leucine-rich repeat	352..376	CDD:275381	18/23 (78%)
		leucine-rich repeat	377..402	CDD:275381	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588032
Domainoid	1	1.000	133	1.000	Domainoid score	I5026
eggNOG	1	0.900	-	-		E1_KOG4341
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1259
OMA	1	1.010	-	-		QHG52856
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	1	1.000	-	-		FOG0002896
OrthoInspector	1	1.000	-	-		otm26570
orthoMCL	1	0.900	-	-		OOG6_101086
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	1	1.000	-	-		X1911
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840