DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9003 and Fbxl13

DIOPT Version :9

Sequence 1:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	XP_011248071.1	Gene:	Fbxl13 / 320118	MGIID:	2443416	Length:	889	Species:	Mus musculus

Alignment Length:	398	Identity:	109/398 - (27%)
Similarity:	194/398 - (48%)	Gaps:	31/398 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 IKQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGSSWQKINLFDFQRDIEGPVIENISQRC 304
            |..||::.:|::|.||....:..|::|.:.|..:...||.|   |..||.      .::||:.:|
Mouse   240 ISVLPEQAILQIFLYLTFKDMMACSRVNRSWMAMIQRGSLW---NSIDFS------TVKNIADKC 295

  Fly   305 --------RGFLKSLSLRGCQSVGDQSVRTL--ANHCHNIEHLDLSDCKKITDISTQSISRYCSK 359
                    |..:..|:.|||    |...:||  .:||.|::.|::|||:..||.|.:.||..|..
Mouse   296 VVTTLQKWRLNVLRLNFRGC----DFRTKTLKAVSHCKNLQELNVSDCQSFTDESMRHISEGCPG 356

  Fly   360 LTAINLHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENGVE--ALARGCVKLRKFSSKGCKQ 422
            :..:|| |.:.||:.:::.|.....||..:::::|...::.|::  .|..||.||......||.|
Mouse   357 VLYLNL-SNTTITNRTMRLLPRYFHNLQNLSLAYCRKFTDKGLQYLNLGNGCHKLIYLDLSGCTQ 420

  Fly   423 INDNAIMCLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKLQKLCVSKCADLTDLTLLSLSQHN 487
            |:......:|..|..::.|.::...|:||:.::.|...|.::..:.:.....::|....:||..:
Mouse   421 ISVQGFRNIASSCTGIVHLTINDMPTLTDNCVKVLVEKCPRISSVVLIGSPHISDSAFKALSSCD 485

  Fly   488 HLLNTLEVSGCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCEL 552
              |..:...|.:..:|..|:::.||...:..:.:.:|..:||.:|..|:. ...|..|.|::|..
Mouse   486 --LKKIRFEGNKRISDACFKSIDRNYPGINHIYMVDCKGLTDSSLKSLSL-LKQLTVLNLTNCIR 547

  Fly   553 ITDDGIRHLTTGSCAAEILSVLELDNCPLITDRTLEHLVS-CHNLQRIELFDCQLITRTAIRKLK 616
            |.|.|::|...|..:.. |..|.|.||.|:.|.::..|.. |.||..:.|.:|:.:|..||..:.
Mouse   548 IGDIGLKHFFDGPASIR-LRELNLTNCSLLGDSSVIRLSERCPNLHYLNLRNCEHLTDLAIEYIA 611

  Fly   617 NHLPNIKV 624
            :.|..|.|
Mouse   612 SMLSLISV 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	13/44 (30%)
		leucine-rich repeat	280..307	CDD:275381	8/34 (24%)
		AMN1	<308..453	CDD:187754	45/148 (30%)
		leucine-rich repeat	308..327	CDD:275381	5/18 (28%)
		leucine-rich repeat	334..359	CDD:275381	10/24 (42%)
		leucine-rich repeat	360..385	CDD:275381	6/24 (25%)
		leucine-rich repeat	386..411	CDD:275381	6/26 (23%)
		AMN1	<409..586	CDD:187754	45/176 (26%)
		leucine-rich repeat	412..437	CDD:275381	7/24 (29%)
		leucine-rich repeat	438..463	CDD:275381	6/24 (25%)
		leucine-rich repeat	464..515	CDD:275381	9/50 (18%)
		leucine-rich repeat	516..541	CDD:275381	5/24 (21%)
		leucine-rich repeat	542..561	CDD:275381	7/18 (39%)
		leucine-rich repeat	571..595	CDD:275381	9/24 (38%)
		leucine-rich repeat	596..621	CDD:275381	7/24 (29%)
Fbxl13	XP_011248071.1	F-box-like	240..284	CDD:372399	14/46 (30%)
		leucine-rich repeat	255..268	CDD:275381	3/12 (25%)
		leucine-rich repeat	280..306	CDD:275381	8/34 (24%)
		AMN1	306..475	CDD:187754	47/173 (27%)
		leucine-rich repeat	307..330	CDD:275381	9/26 (35%)
		leucine-rich repeat	331..356	CDD:275381	10/24 (42%)
		leucine-rich repeat	357..381	CDD:275381	6/24 (25%)
		leucine-rich repeat	382..409	CDD:275381	6/26 (23%)
		leucine-rich repeat	410..435	CDD:275381	7/24 (29%)
		leucine-rich repeat	436..461	CDD:275381	6/24 (25%)
		leucine-rich repeat	462..484	CDD:275381	3/21 (14%)
		AMN1	473..605	CDD:187754	37/135 (27%)
		leucine-rich repeat	486..511	CDD:275381	6/24 (25%)
		leucine-rich repeat	512..536	CDD:275381	5/24 (21%)
		leucine-rich repeat	537..564	CDD:275381	9/26 (35%)
		leucine-rich repeat	565..590	CDD:275381	9/24 (38%)
		leucine-rich repeat	591..610	CDD:275381	6/18 (33%)
		leucine-rich repeat	617..645	CDD:275381	2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843120
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870