Protein Alignment CG9003 and FBXL2

DIOPT Version :10

• Sequence 1: NP_001097271.1
• Gene: CG9003 / 36244
• FlyBaseID: FBgn0033639
• Length: 651
• Species: Drosophila melanogaster
• Sequence 2: XP_054201991.1
• Gene: FBXL2 / 25827
• HGNCID: 13598
• Length: 479
• Species: Homo sapiens
• Alignment Length: 469
• Identity: 236/469 - (50%)
• Similarity: 316/469 - (67%)
• Gaps: 35/469 - (7%)

  Fly   215 AGSAQDQSEDQSQTFLGATELDDELI-KQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGS 278
            ||:.:...:|.::.|   :..|:.|| |:||||:|||:||:||:|:||||||:.|.||:||||||
Human    14 AGARERAKKDPAEVF---SNNDEGLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGS 75

  Fly   279 SWQKINLFDFQRDIEGPVIENISQRCRGFLKSLSLRGCQSVGDQSVRTLANHCHNIEHLDLSDCK 343
            :||:|:||:||.|:||.|:||||:||.|||:.||||||..|||.|::|.|.:|.|||||:|:.|.
Human    76 NWQRIDLFNFQTDVEGRVVENISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCT 140

  Fly   344 KITDISTQSISRYCSKLTAINLHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENGVEALARG 408
            ||||.:..|:||:||||..::|.||.:||::|||.:|:||.||..:|:|||..|:::|:|||.||
Human   141 KITDSTCYSLSRFCSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRG 205

  Fly   409 CVKLRKFSSKGCKQINDNAIMCLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKLQKLCVSKCA 473
            |..|:....:||.|:.|.|:..:..||.:|:.|||.||..|||..:.|:...||:||.||:|.|:
Human   206 CRGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCS 270

  Fly   474 DLTDLTLLSLSQHNHLLNTLEVSGCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATG 538
            :|||.:|.:|..:...|..||.:.|.:.||.||..|.|||..||:||||||..|||.||..|:..
Human   271 NLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIH 335

  Fly   539 CPSLEKL-------------------------------TLSHCELITDDGIRHLTTGSCAAEILS 572
            ||.|:.|                               :||||||||||||.||:..:|..|.|.
Human   336 CPKLQALVSLSFSDIIHLLKMKEPSHHNKKLFGFSFCKSLSHCELITDDGILHLSNSTCGHERLR 400

  Fly   573 VLELDNCPLITDRTLEHLVSCHNLQRIELFDCQLITRTAIRKLKNHLPNIKVHAYFAPGTPPAVT 637
            |||||||.||||..||||.:|..|:|:||:|||.:||..|::::..||::||||||||.|||...
Human   401 VLELDNCLLITDVALEHLENCRGLERLELYDCQQVTRAGIKRMRAQLPHVKVHAYFAPVTPPTAV 465

  Fly   638 SGHRPRYCRCCEIL 651
            :|...|.||||.||
Human   466 AGSGQRLCRCCVIL 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box_FBXL2-like	237..281	CDD:438887	30/44 (68%)
		leucine-rich repeat	280..307	CDD:275381	17/26 (65%)
		AMN1	<308..453	CDD:187754	74/144 (51%)
		leucine-rich repeat	308..327	CDD:275381	11/18 (61%)
		leucine-rich repeat	334..359	CDD:275381	14/24 (58%)
		leucine-rich repeat	360..385	CDD:275381	12/24 (50%)
		leucine-rich repeat	386..411	CDD:275381	13/24 (54%)
		AMN1	<409..586	CDD:187754	90/207 (43%)
		leucine-rich repeat	412..437	CDD:275381	8/24 (33%)
		leucine-rich repeat	438..463	CDD:275381	11/24 (46%)
		leucine-rich repeat	464..515	CDD:275381	23/50 (46%)
		leucine-rich repeat	516..541	CDD:275381	15/24 (63%)
		leucine-rich repeat	542..561	CDD:275381	14/49 (29%)
		leucine-rich repeat	571..595	CDD:275381	17/23 (74%)
		leucine-rich repeat	596..621	CDD:275381	11/24 (46%)
FBXL2	XP_054201991.1	F-box_FBXL2-like	34..78	CDD:438887	30/43 (70%)
		leucine-rich repeat	77..104	CDD:275381	17/26 (65%)
		AMN1	<101..248	CDD:187754	75/146 (51%)
		leucine-rich repeat	105..124	CDD:275381	11/18 (61%)
		leucine-rich repeat	131..156	CDD:275381	14/24 (58%)
		leucine-rich repeat	157..182	CDD:275381	12/24 (50%)
		leucine-rich repeat	183..208	CDD:275381	13/24 (54%)
		AMN1	193..423	CDD:187754	102/229 (45%)
		leucine-rich repeat	209..234	CDD:275381	8/24 (33%)
		leucine-rich repeat	235..260	CDD:275381	11/24 (46%)
		leucine-rich repeat	261..286	CDD:275381	11/24 (46%)
		leucine-rich repeat	287..312	CDD:275381	12/24 (50%)
		leucine-rich repeat	313..338	CDD:275381	15/24 (63%)
		leucine-rich repeat	339..389	CDD:275381	14/49 (29%)
		leucine-rich repeat	399..418	CDD:275381	14/18 (78%)