DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9003 and FBXL2

DIOPT Version :9

Sequence 1:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001336245.1	Gene:	FBXL2 / 25827	HGNCID:	13598	Length:	454	Species:	Homo sapiens

Alignment Length:	448	Identity:	232/448 - (51%)
Similarity:	306/448 - (68%)	Gaps:	32/448 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 DDELI-KQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGSSWQKINLFDFQRDIEGPVIEN 299
            |:.|| |:||||:|||:||:||:|:||||||:.|.||:||||||:||:|:||:||.|:||.|:||
Human     7 DEGLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQTDVEGRVVEN 71

  Fly   300 ISQRCRGFLKSLSLRGCQSVGDQSVRTLANHCHNIEHLDLSDCKKITDISTQSISRYCSKLTAIN 364
            ||:||.|||:.||||||..|||.|::|.|.:|.|||||:|:.|.||||.:..|:||:||||..::
Human    72 ISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLD 136

  Fly   365 LHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENGVEALARGCVKLRKFSSKGCKQINDNAIM 429
            |.||.:||::|||.:|:||.||..:|:|||..|:::|:|||.|||..|:....:||.|:.|.|:.
Human   137 LTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGCRGLKALLLRGCTQLEDEALK 201

  Fly   430 CLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKLQKLCVSKCADLTDLTLLSLSQHNHLLNTLE 494
            .:..||.:|:.|||.||..|||..:.|:...||:||.||:|.|::|||.:|.:|..:...|..||
Human   202 HIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQILE 266

  Fly   495 VSGCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKL-------------- 545
            .:.|.:.||.||..|.|||..||:||||||..|||.||..|:..||.|:.|
Human   267 AARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALVSLSFSDIIHLLKM 331

  Fly   546 -----------------TLSHCELITDDGIRHLTTGSCAAEILSVLELDNCPLITDRTLEHLVSC 593
                             :||||||||||||.||:..:|..|.|.|||||||.||||..||||.:|
Human   332 KEPSHHNKKLFGFSFCKSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHLENC 396

  Fly   594 HNLQRIELFDCQLITRTAIRKLKNHLPNIKVHAYFAPGTPPAVTSGHRPRYCRCCEIL 651
            ..|:|:||:|||.:||..|::::..||::||||||||.|||...:|...|.||||.||
Human   397 RGLERLELYDCQQVTRAGIKRMRAQLPHVKVHAYFAPVTPPTAVAGSGQRLCRCCVIL 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	32/45 (71%)
		leucine-rich repeat	280..307	CDD:275381	17/26 (65%)
		AMN1	<308..453	CDD:187754	74/144 (51%)
		leucine-rich repeat	308..327	CDD:275381	11/18 (61%)
		leucine-rich repeat	334..359	CDD:275381	14/24 (58%)
		leucine-rich repeat	360..385	CDD:275381	12/24 (50%)
		leucine-rich repeat	386..411	CDD:275381	13/24 (54%)
		AMN1	<409..586	CDD:187754	90/207 (43%)
		leucine-rich repeat	412..437	CDD:275381	8/24 (33%)
		leucine-rich repeat	438..463	CDD:275381	11/24 (46%)
		leucine-rich repeat	464..515	CDD:275381	23/50 (46%)
		leucine-rich repeat	516..541	CDD:275381	15/24 (63%)
		leucine-rich repeat	542..561	CDD:275381	14/49 (29%)
		leucine-rich repeat	571..595	CDD:275381	17/23 (74%)
		leucine-rich repeat	596..621	CDD:275381	11/24 (46%)
FBXL2	NP_001336245.1	F-box-like	15..56	CDD:315592	29/40 (73%)
		leucine-rich repeat	52..79	CDD:275381	17/26 (65%)
		AMN1	<76..223	CDD:332986	75/146 (51%)
		leucine-rich repeat	80..99	CDD:275381	11/18 (61%)
		leucine-rich repeat	106..131	CDD:275381	14/24 (58%)
		leucine-rich repeat	132..157	CDD:275381	12/24 (50%)
		leucine-rich repeat	158..183	CDD:275381	13/24 (54%)
		AMN1	168..398	CDD:332986	102/229 (45%)
		leucine-rich repeat	184..209	CDD:275381	8/24 (33%)
		leucine-rich repeat	210..235	CDD:275381	11/24 (46%)
		leucine-rich repeat	236..261	CDD:275381	11/24 (46%)
		leucine-rich repeat	262..287	CDD:275381	12/24 (50%)
		leucine-rich repeat	288..313	CDD:275381	15/24 (63%)
		leucine-rich repeat	314..364	CDD:275381	14/49 (29%)
		leucine-rich repeat	374..393	CDD:275381	14/18 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153018
Domainoid	1	1.000	135	1.000	Domainoid score	I4981
eggNOG	1	0.900	-	-		E1_KOG4341
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	520	1.000	Inparanoid score	I1275
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52856
OrthoDB	1	1.010	-	-		D1046098at2759
OrthoFinder	1	1.000	-	-		FOG0002896
OrthoInspector	1	1.000	-	-		otm42042
orthoMCL	1	0.900	-	-		OOG6_101086
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	1	1.000	-	-		X1911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840